The efficacy of a photolyase-based device on the cancerization field: A clinical and thermographic study

Background: at skin level,a cancerization field (cf) indicates some chronically photoexposed areas in which,besides a primary tumor,histological or biomolecular modifications without clinical signs are present. active telethermography (att) allows us to observe the imaging of a hyperthermic halo (hh) surrounding the tumor. the authors hypothesize hh as a possible expression of cf. objectives: the aim of this study were to verify whether hhs have the same histological or immunohistochemical characteristics as the cf and,secondly,to evaluate the efficacy of a device containing the enzyme photolyase in modifying thermographic parameters in these area. methods: the study included 30 patients affected by actinic keratosis,evaluated clinically and by att at time 0 and after 3,6 and 9 months. results: the att showed the presence of hhs in all the patients and,after the treatment,a significant modification of both the extension of these areas and the thermal parameters. in 5 patients for whom,while operated,two other biopsies were performed,respectively on the hh and on a perilesional non-hyperthermic area,in the hh,we detected a p53 and ki 67 over-expression. conclusions: our results indicate that att could represent a useful paraclinic method in identifying cfs in subjects at risk. © 2015 laino et al.