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Phosphorylated AKT1 is associated with poor prognosis in esophageal squamous cell carcinoma
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نویسنده
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zhu z. ,yu w. ,fu x. ,sun m. ,wei q. ,li d. ,chen h. ,xiang j. ,li h. ,zhang y. ,zhao w. ,zhao k.
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منبع
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journal of experimental and clinical cancer research - 2015 - دوره : 34 - شماره : 1
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چکیده
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Background: the epidermal growth factor receptor (egfr) signaling pathway is important in regulating biological behaviors in many malignancies. we explored whether expression and activation of egfr and several components on its downstream pathways have prognostic significance in patients with esophageal squamous cell carcinoma (escc). methods: expression of egfr,phosphorylated (p)-egfr,akt1,p-akt1,akt2,p-akt2,erk1,erk2,p-erk1/2,stat3,and p-stat3 was assessed by immunohistochemical analysis of tissue microarrays for 275 escc patients who had undergone complete three-field lymphadenectomy. spearman rank correlation tests were used to determine the relationships among protein expression,and cox regression analyses were performed to determine the prognostic factors on overall survival (os). results: p-egfr expression was correlated statistically with all of the other phosphorylated markers. gender,n stage,and p-akt1 expression were found to be independent prognostic factors for os. increased expression of p-akt1 was associated with decreased patient survival. egfr and p-egfr expression was not significantly associated with patient survival. conclusion: activation of akt1 was associated with poor prognosis in escc. © 2015 zhu et al.
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کلیدواژه
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Epidermal growth factor receptor; Esophageal carcinoma; Esophageal squamous cell carcinoma; Immunohistochemistry; p-AKT1; Prognosis; Prognostic factor
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آدرس
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department of radiation oncology,fudan university shanghai cancer center,270 dong an road,shanghai,200032,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of radiation oncology,six hospital of jiao tong university,shanghai, China, department of radiation oncology,fudan university shanghai cancer center,270 dong an road,shanghai,200032,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of pathology,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of pathology,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of pathology,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of thoracic surgery,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of thoracic surgery,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of thoracic surgery,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of thoracic surgery,fudan university shanghai cancer center,shanghai,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of radiation oncology,fudan university shanghai cancer center,270 dong an road,shanghai,200032,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China, department of radiation oncology,fudan university shanghai cancer center,270 dong an road,shanghai,200032,china,department of oncology,shanghai medical college,fudan university,270 dong an road,shanghai,200032, China
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Authors
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