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The circadian clock in oral health and diseases
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نویسنده
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papagerakis s. ,zheng l. ,schnell s. ,sartor m.a. ,somers e. ,marder w. ,mcalpin b. ,kim d. ,mchugh j. ,papagerakis p.
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منبع
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journal of dental research - 2014 - دوره : 93 - شماره : 1 - صفحه:27 -35
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چکیده
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Most physiological processes in mammals display circadian rhythms that are driven by the endogenous circadian clock. this clock is comprised of a central component located in the hypothalamic suprachiasmatic nucleus and subordinate clocks in peripheral tissues. circadian rhythms sustain 24-hour oscillations of a large number of master genes controlling the correct timing and synchronization of diverse physiological and metabolic processes within our bodies. this complex regulatory network provides an important communication link between our brain and several peripheral organs and tissues. at the molecular level,circadian oscillations of gene expression are regulated by a family of transcription factors called clock genes. dysregulation of clock gene expression results in diverse human pathological conditions,including autoimmune diseases and cancer. there is increasing evidence that the circadian clock affects tooth development,salivary gland and oral epithelium homeostasis,and saliva production. this review summarizes current knowledge of the roles of clock genes in the formation and maintenance of oral tissues,and discusses potential links between oral clocks and diseases such as head and neck cancer and sjögren's syndrome. © international & american associations for dental research.
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کلیدواژه
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autoimmune diseases; clock genes; oral cancer; salivary glands; Sjögren's syndrome; tooth
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آدرس
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department of otolaryngology,medical school,university of michigan,ann arbor,mi,united states,department of periodontics and oral medicine,school of dentistry,university of michigan,ann arbor,mi, United States, department of otolaryngology,medical school,university of michigan,ann arbor,mi,united states,department of orthodontics and pediatric dentistry,school of dentistry,university of michigan,ann arbor,mi, United States, department of molecular and integrative physiology,university of michigan medical school,ann arbor,mi,united states,center for computational medicine and bioinformatics,university of michigan,ann arbor,mi,united states,center for organogenesis,university of michigan,ann arbor,mi, United States, center for computational medicine and bioinformatics,university of michigan,ann arbor,mi,united states,department of computational medicine and bioinformatics,medical school,university of michigan,ann arbor,mi, United States, department of internal medicine,division of rheumatology,university of michigan,ann arbor,mi,united states,department of obstetrics and gynecology,medical school,university of michigan,ann arbor,mi,united states,department of environmental health sciences,school of public health,university of michigan,ann arbor,mi, United States, department of internal medicine,division of rheumatology,university of michigan,ann arbor,mi, United States, department of orthodontics and pediatric dentistry,school of dentistry,university of michigan,ann arbor,mi, United States, department of orthodontics and pediatric dentistry,school of dentistry,university of michigan,ann arbor,mi, United States, department of pathology,medical school,university of michigan,ann arbor,mi, United States, department of orthodontics and pediatric dentistry,school of dentistry,university of michigan,ann arbor,mi,united states,center for computational medicine and bioinformatics,university of michigan,ann arbor,mi,united states,center for organogenesis,university of michigan,ann arbor,mi, United States
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Authors
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