Zoledronate and ion-releasing resins impair dentin collagen degradation

This study analyzed the amounts of solubilized telopeptides cross-linked carboxyterminal telopeptide of type i collagen (ictp) and c-terminal crosslinked telopeptide of type i collagen (ctx) derived from matrix-metalloproteinases (mmps) and cysteine cathepsins (ctps) subsequent to application of a filler-free (res.a) or an ion-releasing resin (res.b) to ethylenediaminetetraacetic acid (edta)-demineralized dentin with or without zoledronate-containing primer (zol-primer) pre-treatment. the chemical modification induced following treatments and artificial saliva (as) storage was also analyzed through attenuated total reflection fourier transform infrared spectroscopy (atr-ftir). totally edta-demineralized specimens were infiltrated with res.a or res.b with or without zol-primer pre-treatment,light-cured,and immersed in as for up to 4 wk. ictp release was reduced following infiltration with res.b and further reduced when res.b was used with zol-primer; remarkable phosphate mineral uptake was attained after as storage. ctx release was increased in res.a- and res.b-treated dentin. however,when zol-primer was used with res.a,the ctx release fell significantly compared to the other tested resin-infiltration methods. in conclusion,zoledronate offers an additional inhibitory effect to the ion-releasing resins in mmp-mediated collagen degradation. however,zol-primer induces a modest reduction in ctx release only when used with resin-based systems containing no ion-releasing fillers. © international & american associations for dental research.