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Restoring host-microbe homeostasis via selective chemoattraction of tregs
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نویسنده
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garlet g.p. ,sfeir c.s. ,little s.r.
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منبع
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journal of dental research - 2014 - دوره : 93 - شماره : 9 - صفحه:834 -839
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چکیده
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The disruption of host-microbe homeostasis at the site of periodontal disease is considered a key factor for disease initiation and progress. while the downstream mechanisms responsible for the tissue damage per se are relatively well-known (involving various patterns of immune response operating toward periodontal tissue destruction),we are only beginning to understand the complexity of host-microbe interactions in the periodontal environment. unfortunately,most of the research has been focused on the disruption of host-microbe homeostasis instead of focusing on the factors responsible for maintaining homeostasis. in this context,regulatory t-cells (tregs) comprise a cd4+foxp3 +t-cell subset with a unique ability to regulate other leukocyte functions to avoid excessive immune activation and its pathological consequences. tregs act as critical determinants of host-microbe homeostasis,as well as determinants of a balanced host response after the disruption of host-microbe homeostasis by pathogens. in periodontitis,tregs play a protective role,with their natural recruitment being responsible for conversion of active into inactive lesions. with controlled-release technology,it is now possible to achieve a selective chemoattraction of tregs to periodontal tissues,attenuating experimental periodontitis evolution due to the local control of inflammatory immune response and the generation of a pro-reparative environment. © international & american associations for dental research.
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کلیدواژه
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bone regeneration; chemokines; drug delivery systems; inflammation; periodontal disease(s)/periodontitis; regulatory T-Lymphocytes
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آدرس
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department of biological sciences,school of dentistry of bauru,são paulo university (fob/usp),bauru,sp, Brazil, department of bioengineering,university of pittsburgh,pittsburgh,pa,united states,mcgowan institute for regenerative medicine,university of pittsburgh,pittsburgh,pa,united states,department of oral biology,university of pittsburgh,pittsburgh,pa,united states,center for craniofacial regeneration,university of pittsburgh,pittsburgh,pa, United States, department of chemical engineering,university of pittsburgh,pittsburgh,pa,united states,department of bioengineering,university of pittsburgh,pittsburgh,pa,united states,department of immunology,university of pittsburgh,pittsburgh,pa,united states,mcgowan institute for regenerative medicine,university of pittsburgh,pittsburgh,pa,united states,center for craniofacial regeneration,university of pittsburgh,pittsburgh,pa, United States
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Authors
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