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Different requirements for Wnt signaling in tongue myogenic subpopulations
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نویسنده
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zhong z. ,zhao h. ,mayo j. ,chai y.
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منبع
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journal of dental research - 2015 - دوره : 94 - شماره : 3 - صفحه:421 -429
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چکیده
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The tongue is a muscular organ that is essential in vertebrates for important functions,such as food intake and communication. little is known about regulation of myogenic progenitors during tongue development when compared with the limb or trunk region. in this study,we investigated the relationship between different myogenic subpopulations and the function of canonical wnt signaling in regulating these subpopulations. we found that myf5- and myod-expressing myogenic subpopulations exist during embryonic tongue myogenesis. in the myf5-expressing myogenic progenitors,there is a cell-autonomous requirement for canonical wnt signaling for cell migration and differentiation. in contrast,the myod-expressing subpopulation does not require canonical wnt signaling during tongue myogenesis. taken together,our results demonstrate that canonical wnt signaling differentially regulates the myf5- and myod-expressing subpopulations during tongue myogenesis. © international & american associations for dental research 2015.
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کلیدواژه
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craniofacial muscles; Myf5; MyoD; myogenesis; progenitors; Wnt/β-catenin
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آدرس
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department of orthodontics,school of stomatology,peking university,beijing,china,center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,csa 103,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,csa 103,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,csa 103,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,csa 103,los angeles,ca, United States
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Authors
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