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The role of autophagy in salivary gland homeostasis and stress responses
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نویسنده
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morgan-bathke m. ,lin h.h. ,ann d.k. ,limesand k.h.
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منبع
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journal of dental research - 2015 - دوره : 94 - شماره : 8 - صفحه:1035 -1040
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چکیده
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Autophagy is a catabolic process that has been shown to have a role in many cellular processes including the removal of excessive or damaged proteins and protein aggregates. the salivary glands play a critical role in oral health,and their secretory capacity may be critically intertwined with the autophagic process. this review describes the role of autophagy activation in normal salivary gland homeostasis and during the glandular stress responses of therapeutic radiation,ductal ligation,autoimmunity,and salivary gland adenoid cystic carcinoma. © international & american associations for dental research.
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کلیدواژه
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cancer; ductal ligation; radiation; rapalogues; salivary physiology; Sjogren's syndrome
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آدرس
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department of nutritional sciences,university of arizona,1177 east 4th street,shantz 421,tucson,az, United States, department of molecular and cellular biology,beckman research institute,city of hope,duarte,ca, United States, diabetes and metabolic diseases research,beckman research institute,city of hope,duarte,ca, United States, department of nutritional sciences,university of arizona,1177 east 4th street,shantz 421,tucson,az, United States
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Authors
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