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Salivary glands: Stem cells,self-duplication,or both?
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نویسنده
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aure m.h. ,arany s. ,ovitt c.e.
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منبع
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journal of dental research - 2015 - دوره : 94 - شماره : 11 - صفحه:1502 -1507
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چکیده
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Understanding the intrinsic potential for renewal and regeneration within a tissue is critical for the rational design of reparative strategies. maintenance of the salivary glands is widely thought to depend on the differentiation of stem cells. however,there is also new evidence that homeostasis of the salivary glands,like that of the liver and pancreas,relies on self-renewal of differentiated cells rather than a stem cell pool. here,we review the evidence for both modes of turnover and consider the implications for the process of regeneration. we propose that the view of salivary glands as postmitotic and dependent on stem cells for renewal be revised to reflect the proliferative activity of acinar cells and their role in salivary gland homeostasis. © 2015 international & american associations for dental research.
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کلیدواژه
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acinar cells; proliferation; regeneration; stem/progenitor cells; thymidine labeling; tissue homeostasis
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آدرس
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center for oral biology,department of biomedical genetics,university of rochester,school of medicine and dentistry,rochester,ny, United States, center for oral biology,department of biomedical genetics,university of rochester,school of medicine and dentistry,rochester,ny, United States, center for oral biology,department of biomedical genetics,university of rochester,school of medicine and dentistry,rochester,ny, United States
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Authors
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