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Acetylsalicylic acid treatment improves differentiation and immunomodulation of SHED
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نویسنده
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liu y. ,chen c. ,liu s. ,liu d. ,xu x. ,chen x. ,shi s.
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منبع
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journal of dental research - 2015 - دوره : 94 - شماره : 1 - صفحه:209 -218
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چکیده
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Stem cells from exfoliated deciduous teeth (shed) possess multipotent differentiation and immunomodulatory properties. they have been used for orofacial bone regeneration and autoimmune disease treatment. in this study,we show that acetylsalicylic acid (asa) treatment is able to significantly improve shed-mediated osteogenic differentiation and immunomodulation. mechanistically,asa treatment upregulates the telomerase reverse transcriptase (tert)/wnt/β-catenin cascade,leading to improvement of shed-mediated bone regeneration,and also upregulates tert/fasl signaling,leading to improvement of shed-mediated t-cell apoptosis and ameliorating disease phenotypes in dextran sodium sulfate-induced colitis mice. these data indicate that asa treatment is a practical approach to improving shed-based cell therapy. © international & american associations for dental research 2014.
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کلیدواژه
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cell therapy; deciduous teeth; Fas ligand; mesenchymal stem cells; telomerase; Wnt pathway
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آدرس
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department of pediatric dentistry,school of stomatology,china medical university,shenyang,china,center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States, department of pediatric dentistry,school of stomatology,china medical university,shenyang, China, center for craniofacial molecular biology,ostrow school of dentistry,university of southern california,2250 alcazar street,los angeles,ca, United States
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Authors
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