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Elevated serum 25(OH)-vitamin D levels are negatively correlated with molar-incisor hypomineralization
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نویسنده
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kühnisch j. ,thiering e. ,kratzsch j. ,heinrich-weltzien r. ,hickel r. ,heinrich j. ,wichmann h.e. ,sausenthaler s. ,zutavern a. ,chen c.-m. ,schnappinger m. ,rzehak p. ,berdel d. ,von berg a. ,beckmann c. ,groß i. ,koletzko s. ,reinhardt d. ,krauss-etschmann s. ,bauer c.p. ,brockow i. ,grübl a. ,hoffmann u. ,krämer u. ,link e. ,cramer c. ,behrendt h. ,borte m. ,diez u. ,schaaf b. ,lehmann i. ,bauer m. ,gräbsch c. ,röder s. ,schilde m. ,herbarth o. ,dick c. ,magnus j. ,bauer c.p. ,hoffmann u. ,behrendt h. ,grosch j. ,martin f.
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منبع
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journal of dental research - 2015 - دوره : 94 - شماره : 2 - صفحه:381 -387
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چکیده
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To date,the precise etiology of molar-incisor hypomineralization (mih) is uncertain. vitamin d plays a key role in hard tissue formation. therefore,this study aimed to analyze the relationship between serum 25-hydroxy-vitamin d (25(oh)d) status and dental health data obtained from 1,048 children in a 10-year follow-up of the munich giniplus and lisaplus birth cohorts. the dental examination included the diagnosis of mih and recording of (non-)cavitated caries lesions in primary and permanent teeth. serum 25(oh)d concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated,modular system. different logistic regression and poisson hurdle models were calculated. mih was diagnosed in 13.6% of the study population. approximately 16.4% of the children demonstrated caries-related defects (d3-4mfs > 0). the mean season-adjusted concentration of 25(oh)d was 75.8 nmol/l (standard deviation 22.0 nmol/l). after adjusting for sex,age,body mass index,parental education,equivalent income,and television/personal computer (tv/pc) viewing hours,a 10 nmol/l increase in serum 25(oh)d concentrations was significantly associated with a lower odds ratio of having mih (or = 0.89; p = 0.006). furthermore,higher 25(oh)d values were associated with a lower number of caries-affected permanent teeth. it is concluded that elevated serum 25(oh)d concentrations were associated with better dental health parameters. © international & american associations for dental research 2014.
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کلیدواژه
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birth cohort study; caries; dental enamel; developmental defect; epidemiology; prevention
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آدرس
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department of conservative dentistry and periodontology,school of dentistry,ludwig-maximilians-university of munich,munich, Germany, institute of epidemiology i,helmholtz zentrum munich,german research centre for environmental health,neuherberg,germany,dr. von hauner children's hospital,ludwig-maximilians-university munich,munich, Germany, institute of laboratory medicine,clinical chemistry and molecular diagnostics,university hospital leipzig,leipzig, Germany, department of preventive and paediatric dentistry,friedrich-schiller-university of jena,jena, Germany, department of conservative dentistry and periodontology,school of dentistry,ludwig-maximilians-university of munich,munich, Germany, institute of epidemiology i,helmholtz zentrum munich,german research centre for environmental health,neuherberg,germany,helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, helmholtz zentrum münchen,german research center for environmental health,institute of epidemiology,munich, Germany, marien-hospital wesel,department of pediatrics,wesel, Germany, marien-hospital wesel,department of pediatrics,wesel, Germany, marien-hospital wesel,department of pediatrics,wesel, Germany, marien-hospital wesel,department of pediatrics,wesel, Germany, department of pediatrics,ludwig-maximilians-university,munich, Germany, department of pediatrics,ludwig-maximilians-university,munich, Germany, department of pediatrics,ludwig-maximilians-university,munich, Germany, department of pediatrics,technical university,munich, Germany, department of pediatrics,technical university,munich, Germany, department of pediatrics,technical university,munich, Germany, department of pediatrics,technical university,munich, Germany, iuf - leibniz research institute for environmental medicine,düsseldorf, Germany, iuf - leibniz research institute for environmental medicine,düsseldorf, Germany, iuf - leibniz research institute for environmental medicine,düsseldorf, Germany, centre for allergy and environment,technical university,munich, Germany, department of pediatrics,municipal hospital st. georg,leipzig, Germany, department of pediatrics,municipal hospital st. georg,leipzig, Germany, pediatric practice,bad honnef, Germany, helmholtz centre for environmental research - ufz,department of environmental immunology/core facility studies,leipzig, Germany, helmholtz centre for environmental research - ufz,department of environmental immunology/core facility studies,leipzig, Germany, helmholtz centre for environmental research - ufz,department of environmental immunology/core facility studies,leipzig, Germany, helmholtz centre for environmental research - ufz,department of environmental immunology/core facility studies,leipzig, Germany, helmholtz centre for environmental research - ufz,department of environmental immunology/core facility studies,leipzig, Germany, university of leipzig,institute of hygiene and environmental medicine,leipzig, Germany, university of leipzig,institute of hygiene and environmental medicine,leipzig, Germany, university of leipzig,institute of hygiene and environmental medicine,leipzig, Germany, technical university munich,department of pediatrics,munich, Germany, technical university munich,department of pediatrics,munich, Germany, zaum - center for allergy and environment,technical university,munich, Germany, zaum - center for allergy and environment,technical university,munich, Germany, zaum - center for allergy and environment,technical university,munich, Germany
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