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Inflammatory response influences treatment of localized aggressive periodontitis
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نویسنده
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allin n. ,cruz-almeida y. ,velsko i. ,vovk a. ,hovemcamp n. ,harrison p. ,huang h. ,aukhil i. ,wallet s.m. ,shaddox l.m.
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منبع
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journal of dental research - 2016 - دوره : 95 - شماره : 6 - صفحه:635 -641
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چکیده
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We previously reported a systemic hyperinflammatory response to bacterial lipopolysaccharide (lps) in children with localized aggressive periodontitis (lap). additionally,different levels of this response were observed within the lap group. it is unknown whether this hyperinflammatory response influences the clinical response to periodontal treatment in these children. therefore,the goal of this study was to evaluate the influence of lps responsiveness present prior to treatment on the clinical response to treatment within the lap cohort. prior to treatment,peripheral blood was collected from 60 african american participants aged 5 to 21 y,free of systemic diseases,and diagnosed with lap. blood was stimulated with ultrapure lps from escherichia coli,and luminex assays were performed to quantify 14 cytokine/chemokine levels. principal component and cluster analyses were used to find patterns of cytokine/chemokine expression among participants and subdivide them into clusters. three distinct clusters emerged among lap participants: a high responder group (high level of response for infg,il6,and il12p40),a mixed responder group (low for some and high for other cytokines/chemokines),and a low responder group (low overall cytokine/chemokine response). periodontal clinical parameters were compared among these groups prior to and 3,6,and 12 mo following treatment with mechanical debridement and systemic antibiotics. high responders presented the lowest reductions in clinical parameters after treatment,whereas the low responders presented the highest reductions. in our lap participants,distinct patterns of lps response were significantly predictive of changes in clinical parameters after treatment. future studies are needed to evaluate the underlying mechanisms predicting the heterogeneity of lap activity,severity,and response to treatment (clinicaltrials.gov nct01330719). © international & american associations for dental research 2016.
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کلیدواژه
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chemokines; cytokines; inflammation; lipopolysaccharides; periodontal diseases; therapy
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آدرس
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department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, pain research and intervention center of excellence,university of florida,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of oral biology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States, department of periodontology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl,united states,department of oral biology,university of florida,college of dentistry,p.o. box 100434,gainesville,fl, United States
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Authors
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