>
Fa   |   Ar   |   En
   Do Genetic Markers of Inflammation Modify the Relationship between Periodontitis and Nonalcoholic Fatty Liver Disease? Findings from the SHIP Study  
   
نویسنده akinkugbe a.a. ,avery c.l. ,barritt a.s. ,cole s.r. ,lerch m. ,mayerle j. ,offenbacher s. ,petersmann a. ,nauck m. ,völzke h. ,slade g.d. ,heiss g. ,kocher t. ,holtfreter b.
منبع journal of dental research - 2017 - دوره : 96 - شماره : 12 - صفحه:1392 -1399
چکیده    An association between periodontitis and nonalcoholic fatty liver disease (nafld) has been reported by experimental animal and epidemiologic studies. this study investigated whether circulating levels of serum c-reactive protein (crp) and a weighted genetic crp score representing markers of inflammatory burden modify the association between periodontitis and nafld. data came from 2,481 participants of the study of health in pomerania who attended baseline examination that occurred between 1997 and 2001. periodontitis was defined as the percentage of sites (0%,<30%,≥30%) with probing pocket depth (pd) ≥4 mm,and nafld status was determined using liver ultrasound assessment. serum crp levels were assayed at a central laboratory,and single-nucleotide polymorphisms previously identified through genome-wide association studies as robustly associated with serum crp were combined into a weighted genetic crp score (wgscrp). logistic regression models estimated the association between periodontitis and nafld within strata of serum crp and separately within strata of the wgscrp. the prevalence of nafld was 26.4% (95% confidence interval [ci],24.6,28.1) while 17.8% (95% ci,16.0-19.6) had ≥30% of sites with pd ≥4 mm. whereas the wgscrp was not a modifier (pinteraction = 0.8) on the multiplicative scale,serum crp modified the relationship between periodontitis and nafld (pinteraction = 0.01). the covariate-adjusted prevalence odds ratio of nafld comparing participants with ≥30% of sites with pd ≥4 mm to those with no site affected was 2.39 (95% ci,1.32-4.31) among participants with serum crp <1 mg/l. the corresponding estimate was 0.97 (95% ci,0.57-1.66) for participants with serum crp levels of 1 to 3 mg/l and 1.12 (95% ci,0.65-1.93) for participants with serum crp >3 mg/l. periodontitis was positively associated with higher prevalence odds of nafld,and this relationship was modified by serum crp levels. © international & american associations for dental research.
کلیدواژه C-reactive protein; epidemiology; genetic score; hepatic steatosis; inflammatory mediator; periodontal disease
آدرس department of epidemiology,university of north carolina at chapel hill,135 dauer drive cb 7435,chapel hill,nc, United States, department of epidemiology,university of north carolina at chapel hill,135 dauer drive cb 7435,chapel hill,nc, United States, department of gastroenterology and hepatology,university of north carolina at chapel hill,chapel hill,nc, United States, department of epidemiology,university of north carolina at chapel hill,135 dauer drive cb 7435,chapel hill,nc, United States, department of medicine a,university medicine greifswald,greifswald, Germany, department of medicine,ludwig-maximilians university,munich, Germany, department of periodontology,university of north carolina at chapel hill,chapel hill,nc, United States, institute of clinical chemistry and laboratory medicine,university medicine greifswald,ernst-moritz-arndt-university,greifswald, Germany, institute of clinical chemistry and laboratory medicine,university medicine greifswald,ernst-moritz-arndt-university,greifswald, Germany, institute for community medicine,university medicine greifswald,greifswald,germany,german center of diabetes research,site greifswald, Germany, department of dental ecology,university of north carolina at chapel hill,chapel hill,nc, United States, department of epidemiology,university of north carolina at chapel hill,135 dauer drive cb 7435,chapel hill,nc, United States, unit of periodontology,department of restorative dentistry,periodontology,endodontology,and preventive and pediatric dentistry,university medicine greifswald,greifswald, Germany, german center of diabetes research,site greifswald, Germany
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved