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Salivary Immunoglobulins and Prevalent Coronary Artery Disease
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نویسنده
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janket s. ,meurman j.h. ,baird a.e. ,qvarnström m. ,nuutinen p. ,ackerson l.k. ,hong j. ,muthukrishnan p. ,van dyke t.e.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 4 - صفحه:389 -394
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چکیده
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Previous studies examined the serum immunoglobulin levels in relation to coronary artery disease (cad). we hypothesized that the salivary immunoglobulins might better estimate oral infections in this relationship. multivariate logistic regression analyses utilizing the data from 256 angiographically confirmed cad patients and 250 non-cad individuals that controlled for age,sex,smoking,diabetes,total/hdl cholesterol ratio,hypertension,and education revealed the trends that salivary iga was positively and salivary igg was inversely associated with cad. the odds ratios (or) of each increasing quartile of salivary iga were 1.00 (first and second quartiles combined),1.97,and 1.37 (p-value for trend = 0.06),while those for salivary igg were 1.00,0.77,0.60,and 0.51 (p-value for trend = 0.02). additionally,salivary iga correlated positively with c-reactive protein and asymptotic dental score (dental infection score),while igg was inversely associated with these inflammation markers. salivary iga warrants further studies to confirm its role in the risk assessment of cad.
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کلیدواژه
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Coronary artery disease; Infection; Inflammation; Mucosal antigenicity; Salivary immunoglobulins
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آدرس
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general dentistry,boston university,school of dental medicine,100 east newton street,boston,ma 02118,united states,periodontology and oral biology,boston university,school of dental medicine,boston,ma, United States, university of helsinki institute of dentistry,helsinki university,central hospital, Finland, cerebro-vascular disease and stroke,suny downstate medical center,brooklyn,ny, United States, otorhinolaryngology/oral and maxillofacial surgery,kuopio university, Finland, cardiothoracic surgery,kuopio university hospital, Finland, university of massachusetts-lowell, United States, boston university,college of arts and science,boston,ma, United States, general dentistry,boston university,school of dental medicine,100 east newton street,boston,ma 02118,united states,massachusetts general hospital,randomized trial unit,boston,ma, United States, periodontology and oral biology,boston university,school of dental medicine,boston,ma, United States
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Authors
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