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Killing of treponema denticola by mouse peritoneal macrophages
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نویسنده
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gaibani p. ,vocale c. ,ambretti s. ,cavrini f. ,izard j. ,miragliotta l. ,pellegrino m.t. ,sambri v.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 5 - صفحه:521 -526
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چکیده
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Treponema denticola has been identified as an important cause of periodontal disease and hypothesized to be involved in extra-oral infections. the objective of this study was to investigate the role of t. denticola cell length and motility during mouse peritoneal macrophages in vitro uptake. macrophages,incubated under aerobic and anaerobic conditions,produced a similar amount of tnf-α when stimulated with escherichia coli lps. the uptake of flge- and cfpa-deficient mutants of t. denticola was significantly increased compared with the wild-type strain,due to cell size or lack of motility. opsonization with specific antibodies considerably improved the treponemes uptake. these results suggest that macrophages,in addition to other phagocytes,could play an important role in the control of t. denticola infection,and that the raising of specific antibodies could improve the efficacy of the immune response toward t. denticola,either at an oral site or during dissemination.
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کلیدواژه
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Dissemination; Immune response; Innate immunity; Periodontitis; Phagocytosis; Treponemes
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آدرس
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department of haematology and oncology l. and a. seragnoli,university of bologna,st. orsola hospital,9 via g. massarenti,40138 bologna,italy,regional reference centre for emerging infections (crrem),st. orsola hospital,bologna, Italy, department of haematology and oncology l. and a. seragnoli,university of bologna,st. orsola hospital,9 via g. massarenti,40138 bologna, Italy, department of haematology and oncology l. and a. seragnoli,university of bologna,st. orsola hospital,9 via g. massarenti,40138 bologna, Italy, regional reference centre for emerging infections (crrem),st. orsola hospital,bologna, Italy, forsyth institute,boston,ma,united states,harvard dental school of medicine,boston,ma, United States, regional reference centre for emerging infections (crrem),st. orsola hospital,bologna, Italy, regional reference centre for emerging infections (crrem),st. orsola hospital,bologna, Italy, department of haematology and oncology l. and a. seragnoli,university of bologna,st. orsola hospital,9 via g. massarenti,40138 bologna,italy,regional reference centre for emerging infections (crrem),st. orsola hospital,bologna,italy,national institute of biostructures and biosystems,bologna, Italy
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Authors
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