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Apatite containing aspartic acid for selective protein loading
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نویسنده
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uddin m.h. ,matsumoto t. ,ishihara s. ,nakahira a. ,okazaki m. ,sohmura t.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 5 - صفحه:488 -492
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چکیده
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Physico-chemical modifications of hydroxyapatite (hap) materials are considered as pre-requisites for the development of new bioactive carrier materials for drug delivery and tissue engineering applications. since acidic amino acids have well-documented affinities to both hap and basic proteins,hap modified by aspartic acid (asp,acidic amino acid) might be one of the candidate substrates for a basic protein carrier. here,we synthesized hap in the presence of various concentrations of asp and observed that hap crystallinity and other physico-chemical properties were effectively modulated. detailed studies indicated that asp was not incorporated in the hap crystal lattice,but rather was trapped in hap crystals. protein adsorption studies indicated that the hap particles modified by asp had a selective loading capacity for basic protein. therefore,hap particles containing asp might have potential in drug delivery applications,especially as the carrier of basic proteins including bfgf and bmp.
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کلیدواژه
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Aspartic acid; Drug delivery system; Hydroxyapatite; Protein loading.
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آدرس
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department of oromaxillofacial regeneration,osaka university,1-8 yamada-oka,suita,565-0871, Japan, department of oromaxillofacial regeneration,osaka university,1-8 yamada-oka,suita,565-0871, Japan, department of material sciences,osaka prefecture university,1-1 gakuen-cho,sakai,599-8531, Japan, department of material sciences,osaka prefecture university,1-1 gakuen-cho,sakai,599-8531, Japan, department of biomaterials science,hiroshima university,1-2-3 kasumi,minami-ku,hiroshima 734-8553, Japan, department of oromaxillofacial regeneration,osaka university,1-8 yamada-oka,suita,565-0871, Japan
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Authors
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