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Down-regulated genes in mouse dental papillae and pulp
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نویسنده
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sasaki h. ,muramatsu t. ,kwon h.-j. ,yamamoto h. ,hashimoto s. ,jung h.-s. ,shimono m.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 7 - صفحه:679 -683
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چکیده
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Important factors involved in odontogenesis in mouse dental papillae disappear between the pre-and post-natal stages of development. therefore,we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. our goal was to identify,by microarray analysis,which genes were down-regulated. dental papillae were isolated from embryonic 16-day-,18-day- (e16,e18),and post-natal 3-day-old (p3) murine first mandibular molar germs and analyzed by microarray. the number of down-regulated genes was 2269 between e16 and e18,and 3130 between e18 and p3. drastic down-regulation (fold change > 10.0) of adamts4,aldha1a2,and lef1 was observed at both e16 and e18,and quantitative rt-pcr revealed a post-natal reduction in their expression (adamts4,1/3; aldh1a2,1/13; and lef1,1/37). these results suggest that down-regulation of these three genes is an important factor in normal odontogenesis in dental papillae.
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کلیدواژه
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Dental papilla; Dental pulp; Gene expression; Odontogenesis; Tooth morphogenesis
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آدرس
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oral health science center hrc7,tokyo dental college,japan,department of pathology,tokyo dental college,1-2-2 masago,mihama-ku,chiba,261-8502, Japan, oral health science center hrc7,tokyo dental college,japan,department of pathology,tokyo dental college,1-2-2 masago,mihama-ku,chiba,261-8502, Japan, department of oral biology,college of dentistry,yonsei university, South Korea, department of histology,cytology and developmental anatomy,nihon university,school of dentistry at matsudo, Japan, oral health science center hrc7,tokyo dental college,japan,department of pathology,tokyo dental college,1-2-2 masago,mihama-ku,chiba,261-8502, Japan, department of pathology,tokyo dental college,1-2-2 masago,mihama-ku,chiba,261-8502,japan,department of oral biology,college of dentistry,yonsei university, South Korea, oral health science center hrc7,tokyo dental college,japan,department of pathology,tokyo dental college,1-2-2 masago,mihama-ku,chiba,261-8502, Japan
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Authors
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