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SNPs of Fc-gamma receptor genes and chronic periodontitis
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نویسنده
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chai l. ,song y.-q. ,zee k.-y. ,leung w.k.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 7 - صفحه:705 -710
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چکیده
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Genetic polymorphisms of host defense genes might increase risk for periodontitis. this case-control study investigated whether 102 single-nucleotide polymorphisms (snps) in fc gamma receptor (fcgr) genes are associated with chronic periodontitis. cases were 190 hong kong chinese patients with severe chronic periodontitis,and there were 169 periodontitis-free individuals as controls. genotype cc and allele c of rs445509 (p < 0.0001,or = 0.30) of fcgr3a were significantly more prevalent among control individuals than among cases,after adjustment for age,sex,and smoking. smoking was significantly associated with chronic periodontitis (p = 0.003,or = 3.35). within the limitations of this study,snp rs445509 of fcgr3a seem to be negatively associated,while smoking was positively associated,with severe chronic periodontitis among hong kong chinese.
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کلیدواژه
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Chronic periodontitis; IgG.; Polymorphisms; Receptors; Single-nucleotide; Smoking
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آدرس
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faculty of dentistry,university of hong kong,prince philip dental hospital,34 hospital road,hong kong, Hong Kong, department of biochemistry,li ka shing faculty of medicine,university of hong kong,hong kong, Hong Kong, faculty of dentistry,university of hong kong,prince philip dental hospital,34 hospital road,hong kong,hong kong,periodontics,westmead centre for oral health,westmead hospital,nsw, Australia, faculty of dentistry,university of hong kong,prince philip dental hospital,34 hospital road,hong kong, Hong Kong
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Authors
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