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Stimulation of IL-6 cytokines in fibroblasts by toll-like receptors 2
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نویسنده
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souza p.p.c. ,palmqvist p. ,lundgren i. ,lie a. ,costa-neto c.m. ,lundberg p. ,lerner u.h.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 8 - صفحه:802 -807
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چکیده
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The osteotropic interleukin-6 (il-6) types of cytokines il-6,il-11,and leukemia inhibitory factor (lif),but not oncostatin m,are expressed by human gingival fibroblasts,and their expressions are regulated by il-1 and tumor necrosis factor-± (tnf-±). in the present study,we investigated whether signaling through toll-like receptor 2 (tlr2) can affect the expression of these cytokines in human gingival fibroblasts. lipopolysaccharide (lps) from p. gingivalis was found to stimulate il-6 and lif mrna and protein,but not il-11 or osm mrna. using two synthetic ligands acting specifically at tlr2 and sirna knockdown of tlr2,we demonstrated the important role of tlr2 in the stimulation of il-6 and lif in gingival fibroblasts. analysis of these data suggests that signaling through the innate immune system controls the expression of osteotropic cytokines in human gingival fibroblasts. © international & american associations for dental research.
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کلیدواژه
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gingival fibroblasts; IL-11; IL-6; LIF; TLR
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آدرس
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department of oral cell biology,umeå university,901 87 umeå,sweden,department of physiology and pathology,araraquara school of dentistry,são paulo state university,araraquara,são paulo, Brazil, department of oral cell biology,umeå university,901 87 umeå, Sweden, department of oral cell biology,umeå university,901 87 umeå, Sweden, department of oral cell biology,umeå university,901 87 umeå, Sweden, department of physiology and pathology,araraquara school of dentistry,são paulo state university,araraquara,são paulo, Brazil, department of oral cell biology,umeå university,901 87 umeå, Sweden, department of oral cell biology,umeå university,901 87 umeå,sweden,institute for medicine,center of bone and arthritis research,sahlgrenska academy,gothenburg, Sweden
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Authors
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