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A community-based RCT for oral cancer screening with toluidine blue
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نویسنده
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su w.w.-y. ,yen a.m.-f. ,chiu s.y.-h. ,chen t.h.-h.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 9 - صفحه:933 -937
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چکیده
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Early detection of oral premalignant lesions (opmls) by visual inspection with toluidine blue has not been addressed. we conducted a community-based randomized controlled trial to assess whether using toluidine blue as an adjunctive tool for visual screening had a higher detection rate of opmls and could further reduce the incidence of oral cancer. in 2000,in keelung,we randomly assigned a total of 7975 individuals,aged 15 years or older and with high-risk oral habits,to either the toluidine-blue-screened (tbs) group or the visual screening group. results showed 5% more oral premalignant lesions and 79% more oral submucous fibrosis detected in the tbs group than in the control group. after a five-year follow-up ascertaining oral cancer development through linkage to the national cancer registry,the incidence rate in the tbs group (28.0 x 10-5) was non-significantly 21% lower than that in the control group (35.4 × 10-5). © international & american associations for dental research.
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کلیدواژه
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oral cancer; oral premalignant and malignant lesions; randomized controlled trial; screening; toluidine blue
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آدرس
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division of biostatistics,college of public health,national taiwan university,no. 17,hsu-chow road,taipei,100,taiwan,department of otolaryngology head and neck surgery,buddhist tzu chi general hospital,taipei branch,taipei,taiwan,school of medicine,tzu chi university,hualien,taiwan,taipei, Taiwan, division of biostatistics,college of public health,national taiwan university,no. 17,hsu-chow road,taipei,100,taiwan,centre of biostatistics consultation,college of public health,national taiwan university, Taiwan, department and graduate institute of health care management,chang gung university,tao-yuan, Taiwan, division of biostatistics,college of public health,national taiwan university,no. 17,hsu-chow road,taipei,100,taiwan,centre of biostatistics consultation,college of public health,national taiwan university, Taiwan
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Authors
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