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High antibody levels to P. gingivalis in cardiovascular disease
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نویسنده
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bohnstedt s. ,cullinan m.p. ,ford p.j. ,palmer j.e. ,leishman s.j. ,westerman b. ,marshall r.i. ,west m.j. ,seymour g.j.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 9 - صفحه:938 -942
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چکیده
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Recent evidence suggests that strain variation in the serum igg response to porphyromonas gingivalis occurs in periodontal disease and cardiovascular disease (cvd). this study aimed to test the hypothesis that different p. gingivalis strains would elicit different levels of igg,depending on a patients cardiovascular (cv) and periodontal health. for cvd patients,serum antibody levels increased significantly with increasing numbers of deep pockets for all strains of p. gingivalis,except w50 (p < 0.001). we used a two-way analysis of variance to examine differences in antibody responses across several cv and periodontal groups simultaneously. there was a significant interaction effect (p < 0.05) between periodontal status and cv status for antibody levels to atcc33277,uqd605,and su63. this study shows variation in strain type with respect to serum igg response in several cv and periodontal categories,providing further support for the role of the immune response to p. gingivalis in the relationship between periodontal disease and cvd. © international & american associations for dental research.
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کلیدواژه
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cardiovascular disease; periodontal disease; Porphyromonas gingivalis; serum antibodies; strain variation
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آدرس
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university of queensland,school of dentistry,brisbane,qld 4000, Australia, university of queensland,school of medicine,brisbane,qld 4000,australia,department of oral sciences,university of otago,dunedin 9054,nz, New Zealand, university of queensland,school of dentistry,brisbane,qld 4000, Australia, university of queensland,school of medicine,brisbane,qld 4000, Australia, university of queensland,school of dentistry,brisbane,qld 4000,australia,university of queensland,school of medicine,brisbane,qld 4000, Australia, university of queensland,school of medicine,brisbane,qld 4000, Australia, university of queensland,school of dentistry,brisbane,qld 4000, Australia, university of queensland,school of medicine,brisbane,qld 4000, Australia, university of queensland,school of medicine,brisbane,qld 4000,australia,department of oral sciences,university of otago,dunedin 9054,nz, New Zealand
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Authors
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