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   Oral and systemic health correlates of HIV-1 shedding in saliva  
   
نویسنده navazesh m. ,mulligan r. ,kono n. ,kumar s.k.s. ,nowicki m. ,alves m. ,mack w.j.
منبع journal of dental research - 2010 - دوره : 89 - شماره : 10 - صفحه:1074 -1079
چکیده    The relationship among oral and systemic health and hiv shedding in saliva is not well-understood. we hypothesized that oral and systemic health are associated with hiv shedding in saliva of hiv-infected women. saliva from 127 participants enrolled in the women's interagency hiv study (wihs) was collected at repeated visits over a 51/2-year study period (october 1998 through march 2004) and was evaluated for hiv-1 rna. demographic,lifestyle,and systemic and oral health characteristics were evaluated as possible correlates of salivary hiv-1 shedding. multivariate models showed significantly increased risk of hiv-1 shedding in saliva as blood levels of cd4 cell counts decreased (p < 0.0001) and hiv rna increased (p < 0.0001). diabetes (p = 0.002) and a high proportion of gingival bleeding sites (p = 0.01) were associated with increased likelihood,while anti-retroviral therapy (p = 0.0003) and higher levels of stimulated saliva flow rates (p = 0.02) were associated with a lower likelihood of hiv-1 rna shedding in saliva. © 2010 international & american associations for dental research.
کلیدواژه HIV-1 shedding; oral health; saliva
آدرس division of periodontology,diagnostic sciences and dental hygiene,herman ostrow school of dentistry of usc,university of southern california,925 west 34th street,den 4320,los angeles,ca,90089-0641, United States, division of dental public health and pediatric dentistry,herman ostrow school of dentistry of usc,university of southern california,925 west 34th street,den 4320,los angeles,ca,90089-0641, United States, department of preventive medicine,keck school of medicine,university of southern california, United States, division of periodontology,diagnostic sciences and dental hygiene,herman ostrow school of dentistry of usc,university of southern california,925 west 34th street,den 4320,los angeles,ca,90089-0641, United States, department of medicine,keck school of medicine,university of southern california, United States, university of illinois,chicago, United States, department of preventive medicine,keck school of medicine,university of southern california, United States
 
     
   
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