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   Regulation of dental enamel shape and hardness  
   
نویسنده simmer j.p. ,papagerakis p. ,smith c.e. ,fisher d.c. ,rountrey a.n. ,zheng l. ,hu j.c.-c.
منبع journal of dental research - 2010 - دوره : 89 - شماره : 10 - صفحه:1024 -1038
چکیده    Epithelial-mesenchymal interactions guide tooth development through its early stages and establish the morphology of the dentin surface upon which enamel will be deposited. starting with the onset of amelogenesis beneath the future cusp tips,the shape of the enamel layer covering the crown is determined by five growth parameters: the (1) appositional growth rate,(2) duration of appositional growth (at the cusp tip),(3) ameloblast extension rate,(4) duration of ameloblast extension,and (5) spreading rate of appositional termination. appositional growth occurs at a mineralization front along the ameloblast distal membrane in which amorphous calcium phosphate (acp) ribbons form and lengthen. the acp ribbons convert into hydroxyapatite crystallites as the ribbons elongate. appositional growth involves a secretory cycle that is reflected in a series of incremental lines. a potentially important function of enamel proteins is to ensure alignment of successive mineral increments on the tips of enamel ribbons deposited in the previous cycle,causing the crystallites to lengthen with each cycle. enamel hardens in a maturation process that involves mineral deposition onto the sides of existing crystallites until they interlock with adjacent crystallites. neutralization of acidity generated by hydroxyapatite formation is a key part of the mechanism. here we review the growth parameters that determine the shape of the enamel crown as well as the mechanisms of enamel appositional growth and maturation. © 2010 international & american associations for dental research.
کلیدواژه ameloblastin; amelogenin; appositional growth; enamelin; tooth
آدرس department of biologic and materials sciences,university of michigan school of dentistry,1011 n. university,ann arbor,mi 48109-1078, United States, department of orthodontics and pediatric dentistry,university of michigan school of dentistry,1011 n. university,ann arbor,mi 48109-1078, United States, department of biologic and materials sciences,university of michigan school of dentistry,1011 n. university,ann arbor,mi 48109-1078,united states,université de montréal,faculté de médecine dentaire,pavillon roger-gaudry,2900 blvd. édouard-montpetit,montréal,qc h3t 1j4,canada,mcgill university,faculty of dentistry,montreal,qc h3a 2b2, Canada, university of michigan museum of paleontology,1529 ruthven,ann arbor,mi 48109-1079, United States, university of michigan museum of paleontology,1529 ruthven,ann arbor,mi 48109-1079, United States, department of orthodontics and pediatric dentistry,university of michigan school of dentistry,1011 n. university,ann arbor,mi 48109-1078, United States, department of biologic and materials sciences,university of michigan school of dentistry,1011 n. university,ann arbor,mi 48109-1078, United States
 
     
   
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