>
Fa   |   Ar   |   En
   Tea catechin EGCg suppresses the mgl gene associated with halitosis  
   
نویسنده xu x. ,zhou x.d. ,wu c.d.
منبع journal of dental research - 2010 - دوره : 89 - شماره : 11 - صفحه:1304 -1308
چکیده    Epigallocatechin gallate (egcg),the main antimicrobial tea catechin,has been reported to inhibit growth and virulence factors of oral pathogens in vitro. although the mechanism is unclear,the potential of egcg in reducing halitosis caused by volatile sulfur compounds (vscs) has been suggested. this study tested the hypothesis that egcg reduces vscs by suppressing mgl,the gene encoding l-methionine-α-deamino-γ-mercaptomethanelyase,responsible for methyl mercaptan (ch3sh) production by oral anaerobes. in this study,the effect of egcg on in vitro growth,ch3sh production,and mgl gene expression in p. gingivalis w83 was investigated. egcg inhibited growth of p. gingivalis w83 (mic = 97.5 μg/ml) and was bactericidal (mbc = 187.5 μg/ml). at sub-mic levels,egcg inhibited ch3sh production,and mgl mrna and protein expression (p < 0.05). we conclude that egcg may represent a natural and alternative agent to the antimicrobial chemicals currently available for halitosis control. © 2010 international & american associations for dental research. © 2010 international & american associations for dental research.
کلیدواژه epigallocatechin gallate; halitosis; mgl; P. gingivalis; volatile sulfur compounds
آدرس department of pediatric dentistry,college of dentistry,university of illinois at chicago,801 s. paulina street,chicago,il 60612-7212,united states,state key laboratory of oral diseases,sichuan university,chengdu, China, state key laboratory of oral diseases,sichuan university,chengdu, China, department of pediatric dentistry,college of dentistry,university of illinois at chicago,801 s. paulina street,chicago,il 60612-7212, United States
 
     
   
Authors
  
 
 

Copyright 2023
Islamic World Science Citation Center
All Rights Reserved