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Neuron-immune interactions in the sensitized thalamus induced by mustard oil application to rat molar pulp
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نویسنده
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kawamura j. ,kaneko t. ,kaneko m. ,sunakawa m. ,kaneko r. ,chokechanachaisakul u. ,okiji t. ,suda h.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 11 - صفحه:1309 -1314
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چکیده
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We have reported that mustard oil application to the rat dental pulp induces neuronal activation in the thalamus. to address the mechanisms involved in the thalamic changes,we performed neuronal responsiveness recording,immunohistochemistry,and molecular biological analysis. after mustard oil application,neuronal responsiveness was increased in the mediodorsal nucleus. when mk801 (an n-methyl- d-aspartate receptor antagonist) was applied to the mediodorsal nucleus,the enhanced responsiveness was decreased. n-methyl-d-aspartate receptor 2d,glial fibrillary acidic protein,and antigen-presenting cell-related gene mrnas in the contralateral thalamus were up-regulated at 10 minutes after mustard oil application,but were down-regulated within 10 minutes after the antagonist application. ox6-expressing microglia and glial fibrillary acidic protein-expressing astrocytes did not increase until 60 minutes after mustard oil application. these results suggested that the thalamic neurons play some roles in regulating the glial cell activation in the mediodorsal nucleus via n-methyl-d-aspartate receptor 2d during pulp inflammation-induced central sensitization. © 2010 international & american associations for dental research.
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کلیدواژه
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antigen-presenting cell-related molecule; central nervous system; central sensitization.; dental pulp; nerve
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آدرس
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pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo, Japan, pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo,japan,division of cariology,operative dentistry and endodontics,niigata university graduate school of medical and dental sciences,5274 gakkocho-dori 2-bancho,chuo-ku,niigata city 951-8514,niigata, Japan, pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo, Japan, pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo,japan,university hospital,faculty of dentistry,tokyo medical and dental university,tokyo, Japan, department of applied molecular medicine,niigata university graduate school of medical and dental sciences,niigata, Japan, pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo, Japan, division of cariology,operative dentistry and endodontics,niigata university graduate school of medical and dental sciences,5274 gakkocho-dori 2-bancho,chuo-ku,niigata city 951-8514,niigata, Japan, pulp biology and endodontics,graduate school,tokyo medical and dental university,tokyo, Japan
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Authors
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