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Taste genes associated with dental caries
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نویسنده
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wendell s. ,wang x. ,brown m. ,cooper m.e. ,desensi r.s. ,weyant r.j. ,crout r. ,mcneil d.w. ,marazita m.l.
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منبع
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journal of dental research - 2010 - دوره : 89 - شماره : 11 - صفحه:1198 -1202
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چکیده
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Dental caries is influenced by a complex interplay of genetic and environmental factors,including dietary habits. previous reports have characterized the influence of genetic variation on taste preferences and dietary habits. we therefore hypothesized that genetic variation in taste pathway genes (tas2r38,tas1r2,gnat3) may be associated with dental caries risk and/or protection. families were recruited by the center for oral health research in appalachia (cohra) for collection of biological samples,demographic data,and clinical assessment of oral health,including caries scores. multiple single-nucleotide polymorphism (snp) assays for each gene were performed and analyzed by transmission disequilibrium test (tdt) analysis (fbat software) for three dentition groups: primary,mixed,and permanent. statistically significant associations were seen in tas2r38 and tas1r2 for caries risk and/or protection. © 2010 international & american associations for dental research.
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کلیدواژه
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dental caries; genetic association; taste pathway genes; taste preference
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آدرس
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center for oral health research in appalachia,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219,united states,west virginia university,morgantown,wv, United States, department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, center for oral health research in appalachia,university of pittsburgh,pa,united states,department of dental public health and information management,school of dental medicine,university of pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,united states,department of periodontics,school of dentistry,west virginia university,morgantown,wv, United States, center for oral health research in appalachia,university of pittsburgh,pa,united states,dental practice and rural health,west virginia university,morgantown,wv, United States, center for oral health research in appalachia,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219,united states,department of human genetics,graduate school of public health,university of pittsburgh,pa, United States
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Authors
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