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Biomimetic analogs for collagen biomineralization
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نویسنده
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gu l. ,kim y.k. ,liu y. ,ryou h. ,wimmer c.e. ,dai l. ,arola d.d. ,looney s.w. ,pashley d.h. ,tay f.r.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 1 - صفحه:82 -87
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چکیده
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Inability of chemical phosphorylation of sodium trimetaphosphate to induce intrafibrillar mineralization of type i collagen may be due to the failure to incorporate a biomimetic analog to stabilize amorphous calcium phosphates (acp) as nanoprecursors. this study investigated adsorption/desorption characteristics of hydrolyzed and ph-adjusted sodium trimetaphosphate (hpa-na3p 3o9) to collagen. based on those results,a 5-minute treatment time with 2.8 wt% hpa-na3p3o9 was used in a single-layer reconstituted collagen model to confirm that both the acp-stabilization analog and matrix phosphoprotein analog must be present for intrafibrillar mineralization. the results of that model were further validated by complete remineralization of phosphoric-acid-etched dentin treated with the matrix phosphoprotein analog and lined with a remineralizing lining composite,and with the acp-stabilization analog supplied in simulated body fluid. an understanding of the basic processes involved in intrafibrillar mineralization of reconstituted collagen fibrils facilitates the design of novel tissue engineering materials for hard tissue repair and regeneration. © 2011 international & american associations for dental research.
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کلیدواژه
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biomimetic; biomineralization; chemical phosphorylation; collagen; specific binding
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آدرس
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department of operative dentistry and endodontics,guanghua school of stomatology,sun yat-sen university,guangzhou, China, department of conservative dentistry,school of dentistry,kyungpook national university,daegu, South Korea, department of stomatology,tongji hospital,huazhong university of science and technology,wuhan, China, laboratory of advanced materials and processes,mechanical engineering department,university of maryland baltimore county,baltimore,md, United States, department of biostatistics,medical college of georgia,augusta,ga, United States, department of stomatology,first hospital of wuhan,wuhan, China, laboratory of advanced materials and processes,mechanical engineering department,university of maryland baltimore county,baltimore,md, United States, department of biostatistics,medical college of georgia,augusta,ga, United States, department of oral biology,school of dentistry,medical college of georgia,augusta,ga 30912-1129, United States, department of oral biology,school of dentistry,medical college of georgia,augusta,ga 30912-1129,united states,department of endodontics,school of dentistry,medical college of georgia,augusta,ga 30912-1129, United States
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Authors
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