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FGF-2 stimulates periodontal regeneration: Results of a multi-center randomized clinical trial
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نویسنده
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kitamura m. ,akamatsu m. ,machigashira m. ,hara y. ,sakagami r. ,hirofuji t. ,hamachi t. ,maeda k. ,yokota m. ,kido j. ,nagata t. ,kurihara h. ,takashiba s. ,sibutani t. ,fukuda m. ,noguchi t. ,yamazaki k. ,yoshie h. ,ioroi k. ,arai t. ,nakagawa t. ,ito k. ,oda s. ,izumi y. ,ogata y. ,yamada s. ,shimauchi h. ,kunimatsu k. ,kawanami m. ,fujii t. ,furuichi y. ,furuuchi t. ,sasano t. ,imai e. ,omae m. ,yamada s. ,watanuki m. ,murakami s.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 1 - صفحه:35 -40
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چکیده
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The efficacy of the local application of recombinant human fibroblast growth factor-2 (fgf-2) in periodontal regeneration has been investigated. in this study,a randomized,double-blind,placebo-controlled clinical trial was conducted in 253 adult patients with periodontitis. modified widman periodontal surgery was performed,during which 200 μl of the investigational formulation containing 0% (vehicle alone),0.2%,0.3%,or 0.4% fgf-2 was administered to 2- or 3-walled vertical bone defects. each dose of fgf-2 showed significant superiority over vehicle alone (p < 0.01) for the percentage of bone fill at 36 wks after administration,and the percentage peaked in the 0.3% fgf-2 group. no significant differences among groups were observed in clinical attachment regained,scoring approximately 2 mm. no clinical safety problems,including an abnormal increase in alveolar bone or ankylosis,were identified. these results strongly suggest that topical application of fgf-2 can be efficacious in the regeneration of human periodontal tissue that has been destroyed by periodontitis. © 2011 international & american associations for dental research.
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کلیدواژه
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fibroblast growth factor-2; periodontitis; tissue regeneration
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آدرس
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department of periodontology,osaka university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, clinical development department,kaken pharmaceutical co.,ltd.,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,kagoshima university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,nagasaki university hospital,attached school of dentistry,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of odontology,fukuoka dental college medical,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of general dentistry,fukuoka dental college medical,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, division of oral rehabilitation,department of periodontology,kyushu university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, division of oral rehabilitation,department of periodontology,kyushu university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, division of periodontology,operative dentistry and endodontics,department of cariology and periodontology,kyushu dental college hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology and endodontology,tokushima university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology and endodontology,tokushima university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, division of frontier medical science,department of periodontal medicine,hiroshima university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of pathophysiology - periodontal science,biopathological science,okayama university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,asahi university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,aichigakuin university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,aichigakuin university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral biological science,niigata university,medical and dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral biological science,niigata university,medical and dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral and maxillofacial surgery,machida municipal hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontics and endodontics,tsurumi university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of dentistry and oral surgery,keio university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,nihon university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of hard tissue engineering,tokyo medical and dental university,university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of hard tissue engineering,tokyo medical and dental university,university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,nihon university,dental hospital at matsudo,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,tokyo dental,college chiba hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, division of periodontology and endodontology,department of oral biology,tohoku university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of conservative dentistry and oral rehabilitation,dental center,iwate medical university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology and endodontology,division of oral health science,hokkaido university hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of general dentistry,health sciences university,hokkaido hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral rehabilitation,dental and medical clinic,health sciences university of hokkaido,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral medicine and surgery,graduate school of dentistry,tohoku university,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral medicine and surgery,graduate school of dentistry,tohoku university,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of nephrology,nagoya university,graduate school of medicine,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of oral and maxillofacial surgery,izumisano municipal hospital,rinku general medical center,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,osaka university,dental hospital,1-8 yamadaoka,suita,osaka 565-0871, Japan, clinical development department,kaken pharmaceutical co.,ltd.,1-8 yamadaoka,suita,osaka 565-0871, Japan, department of periodontology,osaka university,graduate school of dentistry,1-8 yamadaoka,suita,osaka 565-0871, Japan
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