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Cell therapy for salivary gland regeneration
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نویسنده
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lin c.-y. ,chang f.-h. ,chen c.-y. ,huang c.-y. ,hu f.-c. ,huang w.-k. ,ju s.-s. ,chen m.-h.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 3 - صفحه:341 -346
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چکیده
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There are still no effective therapies for hyposalivation caused by irradiation. in our previous study,bone marrow stem cells can be transdifferentiated into acinar-like cells in vitro. therefore,we hypothesized that transplantation with bone marrow stem cells or acinar-like cells may help functional regeneration of salivary glands. bone marrow stem cells were labeled with nanoparticles and directly co-cultured with acinar cells to obtain labeled acinar-like cells. in total,140 severely combined immune-deficiency mice were divided into 4 groups for cell therapy experiments: (1) normal mice,(2) mice receiving irradiation around their head-and-neck areas; (3) mice receiving irradiation and intra-gland transplantation with labeled stem cells; and (4) mice receiving irradiation and intra-gland transplantation with labeled acinar-like cells. our results showed that salivary glands damaged due to irradiation can be rescued by cell therapy with either bone marrow stem cells or acinar-like cells for recovery of saliva production,body weight,and gland weight. transdifferentiation of bone marrow stem cells into acinar-like cells in vivo was also noted. this study demonstrated that cell therapy with bone marrow stem cells or acinar-like cells can help functional regeneration of salivary glands,and that acinar-like cells showed better therapeutic potentials than those of bone marrow stem cells. © international & american associations for dental research.
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کلیدواژه
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cell therapy; regeneration; salivary gland; stem cell(s); tissue engineering; transdifferentiation
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آدرس
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graduate institute of clinical dentistry,school of dentistry,national taiwan university, Taiwan, institute of biochemistry and molecular biology,college of medicine,national taiwan university, Taiwan, institute of biochemistry and molecular biology,college of medicine,national taiwan university, Taiwan, division of radiation oncology,department of oncology,national taiwan university hospital, Taiwan, biostatistician statistical consulting clinic,national center of excellence for general clinical trial and research,national taiwan university hospital, Taiwan, institute of biochemistry and molecular biology,college of medicine,national taiwan university, Taiwan, graduate institute of clinical dentistry,school of dentistry,national taiwan university, Taiwan, graduate institute of clinical dentistry,school of dentistry,national taiwan university, Taiwan
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Authors
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