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PKCγ in Vc and C1/C2 is involved in trigeminal neuropathic pain
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نویسنده
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nakajima a. ,tsuboi y. ,suzuki i. ,honda k. ,shinoda m. ,kondo m. ,matsuura s. ,shibuta k. ,yasuda m. ,shimizu n. ,iwata k.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 6 - صفحه:777 -781
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چکیده
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The aim of the present study was to clarify the involvement of protein kinase cγ (pkcγ) in the facial neuropathic pain following infraorbital nerve injury. we analyzed the change in pkcγ expression in the trigeminal spinal subnucleus caudalis (vc) and upper cervical spinal cord (c1/c2) following chronic constriction injury of the infraorbital nerve (ion-cci). we also studied ion-cci-mediated mechanical nocifensive behavior in rats. the mechanical head-withdrawal threshold significantly decreased 1 to 14 days after ion-cci compared with that before ion-cci and in sham rats. the expression of pkcγ was significantly larger in the ipsilateral vc compared with the contralateral side in ion-cci rats 3,7,and 14 days after ion-cci. intrathecal (i.t.) administration of the pkcγ inhibitor chelerythrine prevented an increase in the pkcγ expression in the ipsilateral vc. moreover,i.t. administration of chelerythrine annulled ion-cci-mediated reduction in the head-withdrawal threshold. taken together,these findings suggest that pkcγ expression in the vc played an important role in the mechanism of orofacial static mechanical allodynia following trigeminal nerve injury. © 2011 international & american associations for dental research.
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کلیدواژه
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chronic constriction nerve injury; infraorbital nerve; neuropathic pain; PKCγ; trigeminal subnucleus caudalis
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آدرس
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department of orthodontics,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of oral and maxillofacial surgery,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, department of endodontics,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, department of orthodontics,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, department of pedodontics,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, department of orthodontics,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310, Japan, division of functional morphology,dental research center,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,department of physiology,nihon university school of dentistry,1-8-13 kandasurugadai,chiyoda-ku,tokyo 101-8310,japan,division of applied system neuroscience advanced medical research center,nihon university,graduate school of medical science,30-1 ohyaguchi-kamimachi,itabashi-ku,tokyo 173-8610, Japan
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Authors
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