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TGF-β1 promotes migration and invasion of salivary adenoid cystic carcinoma
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نویسنده
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dong l. ,wang y.x. ,li s.l. ,yu g.y. ,gan y.h. ,li d. ,wang c.y.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 6 - صفحه:804 -809
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چکیده
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Salivary adenoid cystic carcinoma (sacc) is one of the most common subtypes of salivary gland carcinomas and frequently metastasizes to distant organs. however,little is known about the molecular mechanisms that promote sacc metastasis. in this study,we report that transforming growth factor (tgf)-β1 was highly expressed in the highly metastatic sacc-lm cell line as compared with its parental low-metastatic sacc-83 cell line. exogenous addition of tgf-β1 induced smad2 phosphorylation and promoted the migration and invasion of sacc-83 cells. consistently,the inhibition of endogenous tgf-β1 signaling in sacc-lm cells by an inhibitor specific to the type i tgf-β1 receptor (tβri) suppressed cell migration and invasion. moreover,we found that tgf-β1 expression was significantly increased in human primary sacc samples with metastasis. taken together,our results suggest that tgf-β1 may play a crucial role in sacc metastasis. © 2011 international & american associations for dental research.
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کلیدواژه
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migration and invasion; salivary adenoid cystic carcinoma; SB431542; Smad2; TGF-β1
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آدرس
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laboratory of oral and maxillofacial surgery,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, laboratory of oral and maxillofacial surgery,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081,china,central laboratory,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, laboratory of oral and maxillofacial surgery,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081,china,central laboratory,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, department of oral and maxillofacial surgery,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, central laboratory,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, laboratory of oral and maxillofacial surgery,peking university school,hospital of stomatology,22 zhongguancun nandajie,haidian district,beijing 100081, China, division of oral biology and medicine,ucla school of dentistry,los angeles,ca 90095, United States
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Authors
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