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Molecular inflammation as an underlying mechanism of the aging process and age-related diseases
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نویسنده
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chung h.y. ,lee e.k. ,choi y.j. ,kim j.m. ,kim d.h. ,zou y. ,kim c.h. ,lee j. ,kim h.s. ,kim n.d. ,jung j.h. ,yu b.p.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 7 - صفحه:830 -840
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چکیده
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Aging is a biological process characterized by time-dependent functional declines that are influenced by changes in redox status and by oxidative stress-induced inflammatory reactions. an organism's pro-inflammatory status may underlie the aging process and age-related diseases. in this review,we explore the molecular basis of low-grade,unresolved,subclinical inflammation as a major risk factor for exacerbating the aging process and age-related diseases. we focus on the redox-sensitive transcription factors,nf-κb and foxo,which play essential roles in the expression of pro-inflammatory mediators and anti-oxidant enzymes,respectively. major players in molecular inflammation are discussed with respect to the age-related up-regulation of pro-inflammatory cytokines and adhesion molecules,cyclooxygenase-2,lipoxygenase,and inducible nitric oxide synthase. the molecular inflammation hypothesis proposed by our laboratory is briefly described to give further molecular insights into the intricate interplay among redox balance,pro-inflammatory gene activation,and chronic age-related inflammatory diseases. the final section discusses calorie restriction as an aging-retarding intervention that also exhibits extraordinarily effective anti-inflammatory activity by modulating gsh redox,nf-κb,sirt1,ppars,and foxos. © international & american associations for dental research.
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کلیدواژه
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Age-related diseases; Aging; Cytokines; Gingivitis; Inflammation; Oxidative stress
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آدرس
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molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, department of pediatrics,university of pittsburgh,rangos research center,pittsburgh,pa 15224, United States, department of neurology and neurological science,school of medicine,stanford university,stanford,ca 94305, United States, division of genome analysis,theragen bio institute aict,kwanggyo technovally,suwon 443-270, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, molecular inflammation research center for aging intervention,pusan national university,busan 609-735,south korea,department of pharmacy,college of pharmacy,pusan national university,gumjung-ku,busan 609-735, South Korea, department of physiology,university of texas,health science center,san antonio,tx 78229-3900, United States
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Authors
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