|
|
|
|
Exclusion of class III malocclusion candidate loci in Brazilian families
|
|
|
|
|
|
|
|
نویسنده
|
cruz r.m. ,hartsfield j.k. ,falcão-alencar g. ,koller d.l. ,pereira r.w. ,mah j. ,ferrari i. ,oliveira s.f.
|
|
منبع
|
journal of dental research - 2011 - دوره : 90 - شماره : 10 - صفحه:1202 -1205
|
|
چکیده
|
The role played by genetic components in the etiology of the class iii phenotype,a class of dental malocclusion,is not yet understood. regions that may be related to the development of class iii malocclusion have been suggested previously. the aim of this study was to search for genetic linkage with 6 microsatellite markers (d1s234,d4s3038,d6s1689,d7s503,d10s1483,and d19s566),near previously proposed candidate regions for class iii. we performed a two-point parametric linkage analysis for 42 affected individuals from 10 brazilian families with a positive class iii malocclusion segregation. analysis of our data indicated that there was no evidence for linkage of any of the 6 microsatellite markers to a class iii locus at θ = zero,with data supporting exclusion for 5 of the 6 markers evaluated. the present work reinforces that class iii is likely to demonstrate locus heterogeneity,and there is a dependency of the genetic background of the population in linkage studies. © 2011 international & american associations for dental research.
|
|
کلیدواژه
|
candidate loci; Class III malocclusion; genetic heterogeneity; linkage analysis; mandibular prognathism; microsatellite markers
|
|
آدرس
|
laboratório de genética,departamento de genética e morfologia,universidade de brasília,cep 70910900 brasília,df,brazil,universidade paulista (unip),brasília,df, Brazil, department of oral health science,college of dentistry,university of kentucky,lexington,ky,united states,department of medical and molecular genetics,indiana university,school of medicine,indianapolis,in, United States, laboratório de genética,departamento de genética e morfologia,universidade de brasília,cep 70910900 brasília,df,brazil,programa de pós-graduação em ciências medicas,faculdade de medicina,universidade de brasília,brasília,df, Brazil, department of medical and molecular genetics,indiana university,school of medicine,indianapolis,in, United States, programa de pós-graduação em ciências genômicas e biotecnologia,universidade católica de brasília,brasília,df, Brazil, department of orthodontics and craniofacial molecular biology,university of southern california,los angeles,ca, United States, laboratório de genética,departamento de genética e morfologia,universidade de brasília,cep 70910900 brasília,df, Brazil, laboratório de genética,departamento de genética e morfologia,universidade de brasília,cep 70910900 brasília,df, Brazil
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|