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A role of oral bacteria in bisphosphonate-induced osteonecrosis of the jaw
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نویسنده
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mawardi h. ,giro g. ,kajiya m. ,ohta k. ,almazrooa s. ,alshwaimi e. ,woo s.-b. ,nishimura i. ,kawai t.
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منبع
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journal of dental research - 2011 - دوره : 90 - شماره : 11 - صفحه:1339 -1345
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چکیده
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No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (bonj). therefore,the present study examined the effects of oral bacteria on the development of bonj-like lesions in a mouse model. in the pamidronate (pam)-treated mice,but not control non-drug-treated mice,tooth extraction followed by oral infection with fusobacterium nucleatum caused bonj-like lesions and delayed epithelial healing,both of which were completely suppressed by a broad-spectrum antibiotic cocktail. furthermore,in both in vitro and in vivo experiments,the combination of pam and fusobacterium nucleatum caused the death of gingival fibroblasts (gfs) and down-regulated their production of keratinocyte growth factor (kgf),which induces epithelial cell growth and migration. therefore,in periodontal tissues pre-exposed to bisphosphonate,bacterial infection at tooth extraction sites caused diminished kgf expression in gfs,leading to a delay in the epithelial wound-healing process that was mitigated by antibiotics. © 2011 international & american associations for dental research.
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کلیدواژه
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bisphosphonate-induced osteonecrosis of the jaw; Fusobacterium nucleatum; gingival fibroblast; KGF; pamidronate; wound healing
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آدرس
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department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115,united states,oral medicine division,faculty of dentistry,king abdulaziz university,p.o. box 80209,jeddah 21589, Saudi Arabia, department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral diagnosis and surgery,school of dentistry of araraquara,unesp-são paulo state university,rua humaitá,1680,sp,14801-903, Brazil, department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115, United States, department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115, United States, department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115,united states,oral medicine division,faculty of dentistry,king abdulaziz university,p.o. box 80209,jeddah 21589, Saudi Arabia, restorative dental sciences department,college of dentistry,university of dammam,p.o. box 1982,dammam 31441, Saudi Arabia, department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115, United States, division of advanced prosthodontics,biomaterials and hospital dentistry,ucla school of dentistry,10833 le conte avenue,los angeles,ca 90095, United States, department of immunology,forsyth institute,245 1st st.,cambridge,ma 02142,united states,department of oral medicine,infection and immunity,harvard school of dental medicine,188 longwood avenue,boston,ma 02115, United States
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Authors
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