Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease

Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (ckd),we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative ckd population as measured by serum c-reactive protein (crp). we examined this hypothesis using the national health and nutrition examination survey 1988-1994 (nhanes iii) dataset including 2303 individuals. we followed the american academy of periodontology (aap)/centers for disease control and prevention (cdc) case definition for periodontitis. we used a cutoff point of 30% sites with (pd) ≤ 5 mm and (cal) ≤ 4 mm to define generalized periodontitis cases. we estimated glomerular filtration rate based on cystatin c levels using the relevant equation. urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. ckd was defined based on egfr < 60 ml/min/1.73m2 and albuminuria ≤ 30 mg/g. periodontitis was found in 427 (12.3%) individuals. of individuals with periodontitis,41.8% had serum crp higher than 0.3 mg/dl compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). when the extent of periodontitis was used as one of the independent variables,the parsimonious model showed a strong independent association between extent of periodontitis and serum crp levels (or = 2.0,ci95% = 1.2-3.6). © 2011 international & american associations for dental research.