|
|
|
|
Genome-wide association scan for childhood caries implicates novel genes
|
|
|
|
|
|
|
|
نویسنده
|
shaffer j.r. ,wang x. ,feingold e. ,lee m. ,begum f. ,weeks d.e. ,cuenco k.t. ,barmada m.m. ,wendell s.k. ,crosslin d.r. ,laurie c.c. ,doheny k.f. ,pugh e.w. ,zhang q. ,feenstra b. ,geller f. ,boyd h.a. ,zhang h. ,melbye m. ,murray j.c. ,weyant r.j. ,crout r. ,mcneil d.w. ,levy s.m. ,slayton r.l. ,willing m.c. ,broffitt b. ,vieira a.r. ,marazita m.l.
|
|
منبع
|
journal of dental research - 2011 - دوره : 90 - شماره : 12 - صفحه:1457 -1462
|
|
چکیده
|
Dental caries is the most common chronic disease in children and a major public health concern due to its increasing incidence,serious health and social co-morbidities,and socio-demographic disparities in disease burden. we performed the first genome-wide association scan for dental caries to identify associated genetic loci and nominate candidate genes affecting tooth decay in 1305 us children ages 3-12 yrs. affection status was defined as 1 or more primary teeth with evidence of decay based on intra-oral examination. no associations met strict criteria for genome-wide significance (p < 10e-7); however,several loci (actn2,mtr,and edaradd,mpped2,and lpo) with plausible biological roles in dental caries exhibited suggestive evidence for association. analyses stratified by home fluoride level yielded additional suggestive loci,including tfip11 in the low-fluoride group,and epha7 and zmpste24 in the sufficient-fluoride group. suggestive loci were tested but not significantly replicated in an independent sample (n = 1695,ages 2-7 yrs) after adjustment for multiple comparisons. this study reinforces the complexity of dental caries,suggesting that numerous loci,mostly having small effects,are involved in cariogenesis. verification/replication of suggestive loci may highlight biological mechanisms and/or pathways leading to a fuller understanding of the genetic risks for dental caries. © 2011 international & american associations for dental research.
|
|
کلیدواژه
|
caries; childhood caries; fluoride(s); genetics; genome-wide association study; genomics
|
|
آدرس
|
department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa, United States, center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of biostatistics,university of washington,seattle,wa, United States, department of biostatistics,university of washington,seattle,wa, United States, center for inherited disease research,johns hopkins university,school of medicine,baltimore,md, United States, center for inherited disease research,johns hopkins university,school of medicine,baltimore,md, United States, department of biostatistics,university of washington,seattle,wa, United States, statens serum institut,department of epidemiology research,copenhagen, Denmark, statens serum institut,department of epidemiology research,copenhagen, Denmark, statens serum institut,department of epidemiology research,copenhagen, Denmark, statens serum institut,department of epidemiology research,copenhagen, Denmark, statens serum institut,department of epidemiology research,copenhagen, Denmark, department of pediatrics,university of iowa,iowa city,ia, United States, department of dental public health and information management,school of dental medicine,university of pittsburgh,pittsburgh,pa, United States, department of periodontics,school of dentistry,west virginia university,morgantown,wv, United States, dental practice and rural health,west virginia university,morgantown,wv, United States, department of preventive and community dentistry,university of iowa college of dentistry,iowa city,ia,united states,department of epidemiology,university of iowa,college of public health,iowa city,ia, United States, department of pediatric dentistry,university of iowa,college of dentistry,iowa city,ia, United States, division of genetics and genomics medicine,department of pediatrics,washington university at st. louis,st. louis,mo, United States, department of preventive and community dentistry,university of iowa college of dentistry,iowa city,ia, United States, center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa,united states,center for craniofacial and dental genetics,department of oral biology,university of pittsburgh,100 technology dr.,pittsburgh,pa 15219, United States
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authors
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|