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   Genome-wide Association Study of Periodontal Pathogen Colonization  
   
نویسنده divaris k. ,monda k.l. ,north k.e. ,olshan a.f. ,lange e.m. ,moss k. ,barros s.p. ,beck j.d. ,offenbacher s.
منبع journal of dental research - 2012 - دوره : 91 - شماره : 7_suppl - صفحه:S21 -S28
چکیده    Pathological shifts of the human microbiome are characteristic of many diseases,including chronic periodontitis. to date,there is limited evidence on host genetic risk loci associated with periodontal pathogen colonization. we conducted a genome-wide association (gwa) study among 1,020 white participants of the atherosclerosis risk in communities study,whose periodontal diagnosis ranged from healthy to severe chronic periodontitis,and for whom “checkerboard” dna-dna hybridization quantification of 8 periodontal pathogens was performed. we examined 3 traits: “high red” and “high orange” bacterial complexes,and “high” aggregatibacter actinomycetemcomitans (aa) colonization. genotyping was performed on the affymetrix 6.0 platform. imputation to 2.5 million markers was based on hapmap ii-ceu,and a multiple-test correction was applied (genome-wide threshold of p < 5 × 10ã¢ë†â€™8). we detected no genome-wide significant signals. however,13 loci,including kcnk1,fbxo38,uhrf2,il33,runx2,trps1,camta1,and vamp3,provided suggestive evidence (p < 5 × 10ã¢ë†â€™6) of association. all associations reported for “red” and “orange” complex microbiota,but not for aa,had the same effect direction in a second sample of 123 african-american participants. none of these polymorphisms was associated with periodontitis diagnosis. investigations replicating these findings may lead to an improved understanding of the complex nature of host-microbiome interactions that characterizes states of health and disease. © 2012,international & american associations for dental research. all rights reserved.
کلیدواژه bacteria; chronic periodontitis; dentistry; genetics; genome-wide association studies; infection
آدرس department of pediatric dentistry,school of dentistry,university of north carolina,228 brauer hall,cb#7450,chapel hill,nc 27599,united states,department of epidemiology,gillings school of global public health,university of north carolina,chapel hill,nc, United States, department of epidemiology,gillings school of global public health,university of north carolina,chapel hill,nc,united states,center for observational research,amgen inc.,thousand oaks,ca, United States, department of epidemiology,gillings school of global public health,university of north carolina,chapel hill,nc,united states,carolina center for genome sciences,university of north carolina,chapel hill,nc, United States, department of epidemiology,gillings school of global public health,university of north carolina,chapel hill,nc, United States, department of genetics,school of medicine,university of north carolina,chapel hill,nc,united states,department of biostatistics,gillings school of global public health,university of north carolina,chapel hill,nc,united states,lineberger comprehensive cancer center,university of north carolina,chapel hill,nc, United States, department of dental ecology,school of dentistry,university of north carolina,chapel hill,nc, United States, department of periodontology,school of dentistry,university of north carolina,chapel hill,nc, United States, department of dental ecology,school of dentistry,university of north carolina,chapel hill,nc, United States, department of periodontology,school of dentistry,university of north carolina,chapel hill,nc, United States
 
     
   
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