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Effects of Xylitol Wipes on Cariogenic Bacteria and Caries in Young Children
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نویسنده
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zhan l. ,cheng j. ,chang p. ,ngo m. ,denbesten p.k. ,hoover c.i. ,featherstone j.d.b.
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منبع
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journal of dental research - 2012 - دوره : 91 - شماره : 7_suppl - صفحه:S85 -S90
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چکیده
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The aim of the study was to investigate the efficacy of the use of xylitol-containing tooth-wipes in preventing dental caries in young children. in a double-blinded randomized controlled clinical trial,44 mothers with active caries and their 6- to 35-month-old children were randomized to xylitol-wipe or placebo-wipe groups. the children's caries scores were recorded at baseline and 1 year. salivary levels of mutans streptococci and lactobacilli were enumerated at baseline,3,6,and 12 months. data were analyzed by intent-to-treat modeling with imputation for caries lesions and a linear mixed-effect model for bacterial levels. significantly fewer children in the xylitol-wipe group had new caries lesions at 1 year compared with those in the placebo-wipe group (p < 0.05). no significant differences between the two groups were observed in levels of mutans streptococci and lactobacilli at all time-points. daily xylitol-wipe application significantly reduced the caries incidence in young children as compared with wipes without xylitol,suggesting that the use of xylitol wipes may be a useful adjunct for caries control in infants (clinicaltrials.gov registration number ct01468727). © 2012,international & american associations for dental research. all rights reserved.
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کلیدواژه
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clinical studies/trials; early childhood caries; lactobacilli; mutans streptococci; transmission; xylitol
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آدرس
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department of preventive and restorative dental sciences,united states,department of orofacial sciences, United States, department of preventive and restorative dental sciences, United States, department of orofacial sciences, United States, department of orofacial sciences, United States, department of orofacial sciences, United States, department of cell and tissue biology,school of dentistry,university of california san francisco,box 0758,707 parnassus ave.,san francisco,ca 94143, United States, department of preventive and restorative dental sciences, United States
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Authors
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