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   Relations of Serum ascorbic acid and α-tocopherol to periodontal disease  
   
نویسنده iwasaki m. ,manz m.c. ,taylor g.w. ,yoshihara a. ,miyazaki h.
منبع journal of dental research - 2012 - دوره : 91 - شماره : 2 - صفحه:167 -172
چکیده    Low concentrations of serum anti-oxidants,including ascorbic acid and α-tocopherol,are associated with higher risks of many inflammatory diseases that interrelate with oral health. the present study examined the longitudinal relationship of serum ascorbic acid and α-tocopherol to periodontal disease in 224 japanese individuals,aged 71 yrs,for whom data were available for the years 1999-2007. participants were classified by tertiles of serum ascorbic acid and of α-tocopherol. full-mouth periodontal status,measured as clinical attachment level (cal),was recorded at baseline and annual follow-up examinations. the number of teeth with a loss of cal ≥ 3 mm at any site over the study period was calculated as 'periodontal disease events'. poisson regression analysis was conducted to assess predictors of periodontal disease events,with serum ascorbic acid and α-tocopherol as the primary predictors of interest. the multivariate adjusted relative risks (95% confidence intervals) in the highest,middle,and lowest tertiles were 1.00 (reference),1.12 (1.01-1.26),and 1.30 (1.16-1.47) for ascorbic acid and 1.00 (reference),1.09 (0.98-1.21),and 1.15 (1.04-1.28) for α-tocopherol,respectively. our findings support the hypothesis that low serum levels of ascorbic acid and α-tocopherol may be a risk factor for periodontal disease in japanese elderly. © 2012 international & american associations for dental research.
کلیدواژه dietary anti-oxidants; elderly; epidemiology; longitudinal study; nutrition; oxidative stress
آدرس department of oral health science,graduate school of medical and dental sciences,niigata university,2-5274 gakkocho-dori,chuo-ku,niigata 951-8514, Japan, department of cariology,restorative sciences and endodontics,university of michigan,school of dentistry,ann arbor, United States, department of preventive and restorative dental sciences,university of california,san francisco, United States, department of oral health science,graduate school of medical and dental sciences,niigata university,2-5274 gakkocho-dori,chuo-ku,niigata 951-8514, Japan, department of oral health science,graduate school of medical and dental sciences,niigata university,2-5274 gakkocho-dori,chuo-ku,niigata 951-8514, Japan
 
     
   
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