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Tracing toothache intensity in the brain
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نویسنده
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brügger m. ,lutz k. ,brönnimann b. ,meier m.l. ,luechinger r. ,barlow a. ,jäncke l. ,ettlin d.a.
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منبع
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journal of dental research - 2012 - دوره : 91 - شماره : 2 - صفحه:156 -160
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چکیده
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Identification of brain regions that differentially respond to pain intensity may improve our understanding of trigeminally mediated nociception. this report analyzed cortical responses to painless and painful electrical stimulation of a right human maxillary canine tooth. functional magnetic resonance images were obtained during the application of five graded stimulus strengths,from below,at,and above the individually determined pain thresholds. study participants reported each stimulus on a visual rating scale with respect to evoked sensation. based on hemodynamic responses of all pooled stimuli,a cerebral network was identified that largely corresponds to the known lateral and medial nociceptive system. further analysis of the five graded stimulus strengths revealed positive linear correlations for the anterior insula bilaterally,the contralateral (left) anterior mid-cingulate,as well as contralateral (left) pregenual cingulate cortices. cerebral toothache intensity coding on a group level can thus be attributed to specific subregions within the cortical pain network. © 2012 international & american associations for dental research.
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کلیدواژه
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facial pain/physiopathology; functional MRI; pain/physiopathology; physical stimulation; toothache/physiopathology
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آدرس
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university of zürich,center of dental medicine,masticatory disorders and special care dentistry,plattenstrasse 11,zürich 8032,switzerland,swiss federal institute of technology,university of zürich,institute of biomedical engineering,zürich, Switzerland, university of zürich,department of psychology,neuropsychology,zürich, Switzerland, university of zürich,department of psychology,neuropsychology,zürich, Switzerland, university of zürich,department of psychology,neuropsychology,zürich, Switzerland, swiss federal institute of technology,university of zürich,institute of biomedical engineering,zürich, Switzerland, consumer healthcare,glaxosmithkline,weybridge, United Kingdom, university of zürich,department of psychology,neuropsychology,zürich, Switzerland, university of zürich,center of dental medicine,masticatory disorders and special care dentistry,plattenstrasse 11,zürich 8032, Switzerland
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Authors
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