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Posterior insular molecular changes in myofascial pain
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نویسنده
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gerstner g.e. ,gracely r.h. ,deebajah a. ,ichesco e. ,quintero a. ,clauw d.j. ,sundgren p.c.
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منبع
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journal of dental research - 2012 - دوره : 91 - شماره : 5 - صفحه:485 -490
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چکیده
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Temporomandibular disorders (tmd) include craniocervical pain conditions with unclear etiologies. central changes are suspected; however,few neuroimaging studies of tmd exist. single-voxel proton magnetic resonance spectroscopy (1h-mrs) was used before and after pressure-pain testing to assess glutamate (glu),glutamine (gln),n-acetylaspartate (naa),and choline (cho) levels in the right and left posterior insulae of 11 individuals with myofascial tmd and 11 matched control individuals. glu levels were significantly lower in all individuals after pain testing. among those with tmd,left-insular gln levels were related to reported pain,left posterior insular naa and cho levels were significantly higher at baseline than in control individuals,and naa levels were significantly correlated with pain-symptom duration,suggesting adaptive changes. the results suggest that significant central cellular and molecular changes can occur in individuals with tmd. © 2012 international & american associations for dental research.
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کلیدواژه
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choline; glutamate; glutamine; magnetic resonance spectroscopy; N-acetyl aspartate; temporomandibular disorders
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آدرس
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department of biologic and materials sciences,school of dentistry,university of michigan,1011 n. university ave.,ann arbor,mi 48109-1078,united states,department of psychology,university of michigan,ann arbor,mi, United States, center for neurosensory disorders,university of north carolina,chapel hill,nc,united states,division of rheumatology,department of internal medicine,university of michigan,ann arbor,mi, United States, department of restorative dentistry,school of dentistry,university of detroit mercy,detroit,mi, United States, department of biologic and materials sciences,school of dentistry,university of michigan,1011 n. university ave.,ann arbor,mi 48109-1078,united states,chronic pain and fatigue research center,university of michigan,ann arbor,mi, United States, department of biologic and materials sciences,school of dentistry,university of michigan,1011 n. university ave.,ann arbor,mi 48109-1078, United States, chronic pain and fatigue research center,university of michigan,ann arbor,mi,united states,department of anesthesiology,university of michigan,ann arbor,mi, United States, department of diagnostic radiology,clinical sciences/lund,university of lund,lund,sweden,department of radiology,university of michigan,ann arbor,mi, United States
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Authors
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