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Anti-biofilm dentin primer with quaternary ammonium and silver nanoparticles
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نویسنده
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cheng l. ,zhang k. ,melo m.a.s. ,weir m.d. ,zhou x. ,xu h.h.k.
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منبع
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journal of dental research - 2012 - دوره : 91 - شماره : 6 - صفحه:598 -604
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چکیده
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Antibacterial bonding agents could combat recurrent caries at the tooth-composite margins. the objectives of this study were to develop novel antibacterial dentin primers containing quaternary ammonium dimethacrylate (qadm) and nanoparticles of silver (nag),and to investigate the effects on dentin bond strength and dental plaque microcosm biofilms for the first time. scotchbond multi-purpose (sbmp) bonding agent was used. qadm and nag were incorporated into sbmp primer,yielding 4 primers: sbmp primer (control),control + 10% qadm (mass),control + 0.05% nag,and control + 10% qadm + 0.05% nag. human saliva was collected to grow microcosm biofilms. the nag particle size (mean ± sd; n = 100) was 2.7 ± 0.6 nm. dentin shear bond strengths (n = 10) with human third molars were approximately 30 mpa for all groups (p > 0.1). qadm-nag-containing primer increased the bacteria inhibition zone by 9-fold,compared with control primer (p < 0.05). qadm-nag-containing primer reduced lactic acid production and colony-forming units of total micro-organisms,total streptococci,and mutans streptococci by an order of magnitude. in conclusion,novel qadm-nag-containing primers were strongly antibacterial without compromising dentin bond strength,and hence are promising to inhibit biofilms and secondary caries. the processing method of incorporating qadm and nag together into the same primer produced the strongest antibacterial effect,which could have a wide applicability to other bonding systems. © 2012 international & american associations for dental research.
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کلیدواژه
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antibacterial dentin primer; bond strength; caries inhibition; dental biomaterials; dental plaque microcosm biofilm; quaternary ammonium salt
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آدرس
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department of endodontics,prosthodontics and operative dentistry,university of maryland,dental school,baltimore,650 west baltimore street,baltimore,md 21201,united states,state key laboratory of oral diseases,west china school of stomatology,sichuan university,chengdu, China, department of endodontics,prosthodontics and operative dentistry,university of maryland,dental school,baltimore,650 west baltimore street,baltimore,md 21201,united states,department of orthodontics,school of stomatology,capital medical university,beijing, China, department of endodontics,prosthodontics and operative dentistry,university of maryland,dental school,baltimore,650 west baltimore street,baltimore,md 21201,united states,faculty of pharmacy,dentistry and nursing,federal university of ceara,fortaleza,ce, Brazil, department of endodontics,prosthodontics and operative dentistry,university of maryland,dental school,baltimore,650 west baltimore street,baltimore,md 21201, United States, state key laboratory of oral diseases,west china school of stomatology,sichuan university,chengdu, China, department of endodontics,prosthodontics and operative dentistry,university of maryland,dental school,baltimore,650 west baltimore street,baltimore,md 21201,united states,center for stem cell biology and regenerative medicine,university of maryland,school of medicine,baltimore,md,united states,marlene and stewart greenebaum cancer center,university of maryland,school of medicine,baltimore,md,united states,department of mechanical engineering,university of maryland,baltimore county,md, United States
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Authors
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