Effect of reveromycin a on experimental tooth movement in OPGâ̂?/â̂? mice

In osteoprotegerin-deficient (opgâ̂?/â̂?) mice,osteoclast activity causes bone resorption to outpace bone formation,leading to the development of severe osteoporosis. such mice are therefore useful for investigating the alveolar bone of patients with osteoporosis. reveromycin a (rm-a) was recently identified as the unique agent acting on osteoclast activation. this study aimed to analyze the effect of rm-a on the orthodontic treatment of opgâ̂?/â̂? mice (a model of osteoporosis patients with high levels of bone turnover). we examined alveolar bone remodeling in opgâ̂?/â̂? and wild-type (wt) mice during continuous tooth movement. the orthodontic force was induced by means of a ni-ti closed-coil spring to move the maxillary first molar for 14 days. rm-a sodium salt (1 mg/kg) was administered intraperitoneally twice daily. in opgâ̂?/â̂? mice,the tooth movement distance was longer,alveolar bone resorption was enhanced,the osteoclast count was greater,and serum alkaline phosphatase and tartrate-resistant acid phosphatase levels were higher relative to those in wt mice. however,the administration of rm-a in opgâ̂?/â̂? mice reduced these parameters. we conclude that rm-a normalizes bone metabolism and loss of alveolar bone during continuous tooth movement in opgâ̂?/â̂? mice. © 2012 international & american associations for dental research.