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Effect of a calcium-silicate-based restorative cement on pulp repair
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نویسنده
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tran x.v. ,gorin c. ,willig c. ,baroukh b. ,pellat b. ,decup f. ,opsahl vital s. ,chaussain c. ,boukpessi t.
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منبع
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journal of dental research - 2012 - دوره : 91 - شماره : 12 - صفحه:1166 -1171
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چکیده
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In cases of pulp injury,capping materials are used to enhance tertiary dentin formation; ca(oh)2 and mta are the current gold standards. the aim of this study was to evaluate the capacity of a new calcium-silicate-based restorative cement to induce pulp healing in a rat pulp injury model. for that purpose,cavities with mechanical pulp exposure were prepared on maxillary first molars of 27 six-week-old male rats,and damaged pulps were capped with either the new calcium-silicate-based restorative cement (biodentine),mta,or ca(oh)2. cavities were sealed with glass-ionomer cement,and the repair process was assessed at several time-points. at day 7,our results showed that both the evaluated cement and mta induced cell proliferation and formation of mineralization foci,which were strongly positive for osteopontin. at longer time-points,we observed the formation of a homogeneous dentin bridge at the injury site,secreted by cells displaying an odontoblastic phenotype. in contrast,the reparative tissue induced by ca(oh)2 showed porous organization,suggesting a reparative process different from those induced by calcium silicate cements. analysis of these data suggests that the evaluated cement can be used for direct pulp-capping. © 2012 international & american associations for dental research.
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کلیدواژه
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animal model; cell differentiation; dental pulp capping; mineralization; odontoblast; reparative dentin
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آدرس
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pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,faculty of odonto-stomatology,university of medicine and pharmacy,ho chi minh city, Viet Nam, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,restorative dentistry and endodontic department,ufr odontology,universite paris descartes,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France, pathologies,imaging and biotherapies of the tooth,dental school,université paris descartes,pres sorbonne paris cité,1 rue maurice,arnoux 92120,france,restorative dentistry and endodontic department,ufr odontology,universite paris descartes,france,ap-hp,odontology departments bretonneau,charles foix,louis mourier,paris, France
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Authors
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