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Clustering tooth surfaces into biologically informative caries outcomes
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نویسنده
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shaffer j.r. ,feingold e. ,wang x. ,weeks d.e. ,weyant r.j. ,crout r. ,mcneil d.w. ,marazita m.l.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 1 - صفحه:32 -37
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چکیده
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Dental caries affects most adults worldwide; however,the risk factors for dental caries do not necessarily exert their effects uniformly across all tooth surfaces. instead,the actions of some risk factors may be limited to a subset of teeth/surfaces. therefore,we used hierarchical clustering on tooth surface-level caries data for 1,068 appalachian adults (ages 18-75 yrs) to group surfaces based on co-occurrence of caries. our cluster analysis yielded evidence of 5 distinct groups of tooth surfaces that differ with respect to caries: (c1) pit and fissure molar surfaces,(c2) mandibular anterior surfaces,(c3) posterior non-pit and fissure surfaces,(c4) maxillary anterior surfaces,and (c5) mid-dentition surfaces. these clusters were replicated in a national dataset (nhanes 1999-2000,n = 3,123). we created new caries outcomes defined as the number of carious tooth surfaces within each cluster. we show that some cluster-based caries outcomes are heritable (i.e.,under genetic regulation; p < 0.05),whereas others are not. likewise,we demonstrate the association between some cluster-based caries outcomes and potential risk factors such as age,sex,educational attainment,and toothbrushing habits. together,these results suggest that the permanent dentition can be subdivided into groups of tooth surfaces that are useful for understanding the factors influencing cariogenesis. © 2013 international & american associations for dental research.
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کلیدواژه
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cluster analysis; dental caries; heritability; hierarchical clustering; permanent dentition; white spots
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آدرس
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department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,west virginia university,morgantown,wv 26506, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261,united states,west virginia university,morgantown,wv 26506, United States, center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pittsburgh,pa 15219,united states,department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa 15261,united states,west virginia university,morgantown,wv 26506, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261, United States, center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,department of dental public health and information management,university of pittsburgh,school of dental medicine,pittsburgh,pa 15261,united states,west virginia university,morgantown,wv 26506, United States, center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,department of periodontics,west virginia university school of dentistry,morgantown,wv 26506,united states,west virginia university,morgantown,wv 26506, United States, dental practice and rural health,west virginia university school of dentistry,morgantown,wv 26506, United States, department of human genetics,graduate school of public health,university of pittsburgh,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pittsburgh,pa 15261,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pittsburgh,pa 15219,united states,department of oral biology,school of dental medicine,university of pittsburgh,pittsburgh,pa 15261,united states,department of psychiatry,school of medicine,university of pittsburgh,pittsburgh,pa,united states,west virginia university,morgantown,wv 26506, United States
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Authors
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