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GWAS of dental caries patterns in the permanent dentition
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نویسنده
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shaffer j.r. ,feingold e. ,wang x. ,lee m. ,tcuenco k. ,weeks d.e. ,weyant r.j. ,crout r. ,mcneil d.w. ,marazita m.l.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 1 - صفحه:38 -44
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چکیده
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The importance of susceptibility genes in the risk for dental caries has been clearly established. while many candidate caries genes have been proposed,to date,few of them have been rigorously validated through observational and experimental studies. moreover,most genetic epidemiological studies have analyzed global caries phenotypes that ignore the possibility that genes may exert differential effects across tooth surfaces of the dentition. therefore,we performed genome-wide association studies (gwas) of 5 novel dental caries phenotypes (developed by clustering the permanent dentition into categories of tooth surfaces based on co-occurrence of caries) to nominate new candidate caries genes. gwas was performed in 920 self-reported white participants,aged 18 to 75 years,with genotype data on 518,997 genetic variants. we identified a significant genetic association between dental caries of the anterior mandibular teeth and lyzl2 (p value = 9e-9),which codes a bacteriolytic agent thought to be involved in host defense. we also identified a significant genetic association between caries of the mid- dentition tooth surfaces and ajap1 (p value = 2e-8),a gene possibly involved in tooth development. suggestive genetic associations were also observed for abcg2,pkd2,the dentin/bone scpp sub-family,ednra,tjfbr1,nkx2-3,ift88,twsg1,il17d,and smad7 (p values < 7e-6). we nominate these novel genes for future study. © 2013 international & american associations for dental research.
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کلیدواژه
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cluster analysis; genetic association; genome-wide association study; genomics; hierarchical clustering; tooth decay
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آدرس
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department of human genetics,graduate school of public health,university of pittsburgh,130 desoto st.,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv, United States, department of human genetics,graduate school of public health,university of pittsburgh,130 desoto st.,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pa, United States, department of human genetics,graduate school of public health,university of pittsburgh,130 desoto st.,pittsburgh,pa 15261,united states,department of biostatistics,graduate school of public health,university of pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,department of dental public health and information management,university of pittsburgh,school of dental medicine,pittsburgh,pa, United States, center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,department of periodontics,west virginia university school of dentistry,morgantown,wv, United States, dental practice and rural health,west virginia university school of dentistry,morgantown,wv, United States, department of human genetics,graduate school of public health,university of pittsburgh,130 desoto st.,pittsburgh,pa 15261,united states,center for oral health research in appalachia,university of pittsburgh,pa,west virginia university,morgantown,wv,united states,center for craniofacial and dental genetics,school of dental medicine,university of pittsburgh,pa,united states,department of oral biology,school of dental medicine,university of pittsburgh,pa,united states,department of psychiatry,school of medicine,university of pittsburgh,pa, United States
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Authors
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