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New paradigms on the transport functions of maturation-stage ameloblasts
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نویسنده
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lacruz r.s. ,smith c.e. ,kurtz i. ,hubbard m.j. ,paine m.l.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 2 - صفحه:122 -129
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چکیده
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Fully matured dental enamel is an architecturally and mechanically complex hydroxyapatite-based bioceramic devoid of most of the organic material that was essential in its making. enamel formation is a staged process principally involving secretory and maturation stages,each associated with major changes in gene expression and cellular function. cellular activities that define the maturation stage of amelogenesis include ion (e.g.,calcium and phosphate) transport and storage,control of intracellular and extracellular ph (e.g.,bicarbonate and hydrogen ion movements),and endocytosis. recent studies on rodent amelogenesis have identified a multitude of gene products that appear to be linked to these cellular activities. this review describes the main cellular activities of these genes during the maturation stage of amelogenesis. © 2012 international & american associations for dental research.
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کلیدواژه
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amelogenesis; biomineralization; enamel; endocytosis; ion transport; pH homeostasis
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آدرس
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center for craniofacial molecular biology,herman ostrow school of dentistry,university of southern california,los angeles, United States, department of anatomy and cell biology,faculty of dentistry,mcgill university,montreal, Canada, division of nephrology,david geffen school of medicine at ucla,los angeles,ca, United States, departments of paediatrics and pharmacology,university of melbourne, Australia, center for craniofacial molecular biology,herman ostrow school of dentistry,university of southern california,los angeles, United States
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Authors
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