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Elevated oral and systemic levels of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in Periodontitis
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نویسنده
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bostanci n. ,öztürk v.o. ,emingil g. ,belibasakis g.n.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 2 - صفحه:161 -165
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چکیده
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The triggering receptor expressed on myeloid cells 1 (trem-1) is a cell-surface receptor of the immunoglobulin superfamily,involved in the propagation of the inflammatory response to bacterial challenge. soluble (s)trem-1 is released from the cell surface during the course of infection and is a useful inflammatory biomarker in the early diagnosis of systemic sepsis. the hypothesis of this study was that oral and systemic levels of strem-1 are elevated in periodontitis. therefore,the aim was to investigate,by elisa,the strem-1 concentrations in saliva and serum of individuals without periodontitis (control) and persons with chronic or generalized aggressive periodontitis. in saliva,strem-1 concentrations were higher in chronic and aggressive periodontitis than in the control group,by 3.3-fold and 5.6-fold,respectively. in serum,these differences were 1.7-fold and 2-fold,respectively. however,there were no significant differences between the two forms of periodontitis,neither in saliva nor in serum. salivary and serum strem-1 levels positively correlated with full-mouth clinical periodontal parameters. in conclusion,the increased oral and systemic levels of strem-1 in periodontitis denote a value for this molecule as a biomarker for the disease and may also have implications in the association between periodontal infections and systemic inflammatory response. © 2012 international & american associations for dental research.
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کلیدواژه
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ELISA; inflammation; periodontal diseases; saliva; serum; TREM-1 protein
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آدرس
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oral translational research,center of dental medicine,university of zürich, Switzerland, oral translational research,center of dental medicine,university of zürich,switzerland,department of periodontology,school of dentistry,ege university,izmir, Turkey, department of periodontology,school of dentistry,ege university,izmir, Turkey, oral microbiology and immunology,center of dental medicine,university of zürich, Germany
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Authors
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