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The role of osteocytes in bone resorption during orthodontic tooth movement
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نویسنده
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matsumoto t. ,iimura t. ,ogura k. ,moriyama k. ,yamaguchi a.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 4 - صفحه:340 -345
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چکیده
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We investigated the roles of osteocytes in osteoclastic bone resorption during orthodontic tooth movement using the transgenic mice in which osteocytes can be specifically ablated. because these transgenic mice express the receptor for diphtheria toxin on the cell surfaces of osteocytes,the injection of diphtheria toxin can ablate their osteocytes in vivo. injection of diphtheria toxin into the transgenic mice significantly increased the number of ablated osteocytes in alveolar bone compared with that in wild-type mice with or without diphtheria toxin injection. increased numbers of ablated osteocytes were observed from day 4 to day 12 after the injection in alveolar bones as well as in cortical bone of the tibiae. we applied the orthodontic force 4 days after the injection of diphtheria toxin,and the distance of tooth movement on day 12 was significantly smaller in transgenic mice than that in control mice. the numbers of osteoclasts and the quantity of eroded bone surface at the compression site were significantly reduced in the transgenic mice injected with diphtheria toxin than in control mice. these results provide in vivo demonstration of osteocyte involvement in osteoclastic bone resorption during orthodontic tooth movement. © 2013 international & american associations for dental research.
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کلیدواژه
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alveolar bone; diphtheria toxin; Dmp1; orthodontics; osteoclast; transgenic mice
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آدرس
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section of oral pathology,graduate school of medical and dental sciences,tokyo medical and dental university,1-5-45 yushima,bunkyo-ku,tokyo 113-8549,japan,maxillofacial orthognathics,graduate school of medical and dental sciences,tokyo medical and dental university,tokyo,japan,global center of excellence program,tokyo medical and dental university,tokyo, Japan, section of oral pathology,graduate school of medical and dental sciences,tokyo medical and dental university,1-5-45 yushima,bunkyo-ku,tokyo 113-8549,japan,global center of excellence program,tokyo medical and dental university,tokyo, Japan, global center of excellence program,tokyo medical and dental university,tokyo, Japan, maxillofacial orthognathics,graduate school of medical and dental sciences,tokyo medical and dental university,tokyo,japan,global center of excellence program,tokyo medical and dental university,tokyo, Japan, section of oral pathology,graduate school of medical and dental sciences,tokyo medical and dental university,1-5-45 yushima,bunkyo-ku,tokyo 113-8549,japan,global center of excellence program,tokyo medical and dental university,tokyo, Japan
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Authors
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