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Common SNPs of amelogeninX (AMELX) and dental caries susceptibility
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نویسنده
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gasse b. ,grabar s. ,lafont a.g. ,quinquis l. ,opsahl vital s. ,davit-béal t. ,moulis e. ,chabadel o. ,hennequin m. ,courson f. ,droz d. ,vaysse f. ,laboux o. ,tassery h. ,al-hashimi n. ,boillot a. ,carel j.c. ,treluyer j.m. ,jeanpierre m. ,beldjord c. ,sire j.y. ,chaussain c.
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منبع
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journal of dental research - 2013 - دوره : 92 - شماره : 5 - صفحه:418 -424
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چکیده
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Genetic approaches have shown that several genes could modify caries susceptibility; amelogeninx (amelx) has been repeatedly designated. here,we hypothesized that amelx mutations resulting in discrete changes of enamel microstructure may be found in children with a severe caries phenotype. in parallel,possible amelx mutations that could explain resistance to caries may be found in caries-free patients. in this study,coding exons of amelx and exon-intron boundaries were sequenced in 399 individuals with extensive caries (250) or caries-free (149) individuals from nine french hospital groups. no mutation responsible for a direct change of amelogenin function was identified. seven single-nucleotide polymorphisms (snps) were found,3 presenting a high allele frequency,and 1 being detected for the first time. three snps were located in coding regions,2 of them being non-synonymous. both evolutionary and statistical analyses showed that none of these snps was associated with caries susceptibility,suggesting that amelx is not a gene candidate in our studied population. © 2013 international & american associations for dental research.
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کلیدواژه
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amelogenesis; clinical trial; enamel; genetic predisposition; mutation; social environment
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آدرس
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umr 7138,université pierre et marie curie,75005 paris, France, biostatistics and epidemiology department,paris descartes university,hotel dieu hospital,paris, France, umr 7138,université pierre et marie curie,75005 paris, France, biostatistics and epidemiology department,paris descartes university,hotel dieu hospital,paris, France, ap-hp,service odontologie bretonneau - louis mourier,hupnvs,france,ea2496,pathologies,imaging and biotherapies of the tooth,sorbonne paris cité,montrouge, France, umr 7138,université pierre et marie curie,75005 paris,france,ap-hp,pediatric dentistry department,charles foix,ivry sur seine, France, chu montpellier,dental school,pediatric dentistry department, France, chu montpellier,dental school,pediatric dentistry department, France, chu clermond ferrand,service odontologie,ea3847, France, ap-hp,service odontologie bretonneau - louis mourier,hupnvs,france,ea4462,dental school,sorbonne paris cité,montrouge, France, chu nancy,dental school,pediatric dentistry department, France, chu toulouse,dental school,pediatric dentistry department, France, chu nantes,service odontologie, France, aix-marseille-université,ufr odontologie,service odontologie,marseille,france,ea 4203,ufr odontologie,université montpellier 1, France, umr 7138,université pierre et marie curie,75005 paris, France, department of periodontology,university paris diderot,rothschild hospital, France, endocrinology department,université paris diderot,robert debré hospital, France, unité de recherche clinique paris centre,ap-hp, France, ap-hp,gdpm-institut cochin,université paris descartes, France, ap-hp,gdpm-institut cochin,université paris descartes, France, umr 7138,université pierre et marie curie,75005 paris, France, ap-hp,service odontologie bretonneau - louis mourier,hupnvs,france,ea2496,pathologies,imaging and biotherapies of the tooth,sorbonne paris cité,montrouge, France
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Authors
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