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   Intrauterine hormone effects on tooth dimensions  
   
نویسنده ribeiro d.c. ,brook a.h. ,hughes t.e. ,sampson w.j. ,townsend g.c.
منبع journal of dental research - 2013 - دوره : 92 - شماره : 5 - صفحه:425 -431
چکیده    The human dentition is a complex adaptive system that is influenced by genetic,epigenetic,and environmental factors. within this system,is sexual dimorphism related to the growth promotion of the y chromosome,or to hormonal influences,or both? this study is the first to investigate both primary and permanent tooth sizes in females from opposite-sex dizygotic (dzos) twin pairs compared with females from dizygotic same-sex (dzss) and monozygotic (mz) twin pairs to indicate the influence of intrauterine male hormone,including the initial testosterone surge,on dental development. serial dental models of the primary,mixed,and permanent dentitions of 134 females from dzos,dzss,and mz twins were examined. mesiodistal,buccolingual,crown height,and intercuspal dimensions of all primary teeth and selected permanent teeth were determined by image analysis. univariate and multivariate analyses showed statistically significantly larger crown size in dzos females in both dentitions,with the crown height dimensions displaying the greatest increase in size. these findings strongly support the twin testosterone transfer (ttt) hypothesis. we propose that the growth-promoting effects of the y chromosome and intrauterine male hormone levels influence different tooth dimensions and contribute differentially to the sexual dimorphism of human teeth. © 2013 international & american associations for dental research.
کلیدواژه dentition; genetics; odontogenesis; testosterone; twins; Y chromosome
آدرس school of dentistry,university of adelaide,adelaide,5005,australia,international collaborating network in oro-facial genetics and development, United Kingdom, school of dentistry,university of adelaide,adelaide,5005,australia,queen mary university of london,london,united kingdom,international collaborating network in oro-facial genetics and development,united kingdom,kings college london, United Kingdom, school of dentistry,university of adelaide,adelaide,5005,australia,international collaborating network in oro-facial genetics and development, United Kingdom, school of dentistry,university of adelaide,adelaide,5005, Australia, school of dentistry,university of adelaide,adelaide,5005,australia,international collaborating network in oro-facial genetics and development, United Kingdom
 
     
   
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